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dc.contributor.authorLiu, Zhaowei
dc.contributor.authorRen, Guogang
dc.contributor.authorZhang, Tao
dc.contributor.authorYang, Zhuo
dc.date.accessioned2011-10-10T09:01:18Z
dc.date.available2011-10-10T09:01:18Z
dc.date.issued2011-10
dc.identifier.citationLiu , Z , Ren , G , Zhang , T & Yang , Z 2011 , ' The inhibitory effects of nano-Ag on voltage-gated potassium currents of hippocampal CA1 neurons ' Environmental Toxicology , vol. 26 , no. 5 , pp. 552-558 . https://doi.org/10.1002/tox.20586
dc.identifier.issn1520-4081
dc.identifier.otherPURE: 406213
dc.identifier.otherPURE UUID: 5a503ea7-ba0b-4d97-a143-966245951816
dc.identifier.otherWOS: 000295035600013
dc.identifier.otherScopus: 80052579128
dc.identifier.urihttp://hdl.handle.net/2299/6613
dc.descriptionThe definitive version can be found at: http://onlinelibrary.wiley.com/ Copyright Wiley-Blackwell [Full text of this article is not available in the UHRA]
dc.description.abstractThe application of the nano-sized materials continues to grow at a rapid rate in the fields of medicine, biotechnology, and environmental technology. Voltage-gated potassium currents play a key role in excitable cellular viability and function, especially in the central nervous system. The aim of this study was to investigate the actions of silver nano-particles (nano-Ag) on voltage-activated potassium currents in hippocampal CA1 neurons using whole cell patch-clamp technique. The hydrodynamic mean diameter of nano-Ag (10(-5) g mL(-1)) was 223.9 nm in artificial cerebrospinal fluid (ACSF). Both types, transient potassium (I-A) and delayed rectifier potassium (I-K) current amplitudes were inhibited by the nano-Ag (10(-5) g mL(-1)). The nano-Ag particles produced a hyperpolarizing shift in the activation-voltage curve of I-K and inactivation-voltage curve of I-A and also delayed the recovery of I-A from inactivation. The results suggest that nano-Ag may have potential to alter the excitability of neurons by depressing the potassium channels. (C) 2010 Wiley Periodicals, Inc. Environ Toxicol 26: 552-558, 2011.en
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofEnvironmental Toxicology
dc.subjectnano Ag
dc.subjectpyramidal neurons
dc.subjecttransient outward potassium current (I-A)
dc.subjectdelayed rectifier potassium current (I-K)
dc.titleThe inhibitory effects of nano-Ag on voltage-gated potassium currents of hippocampal CA1 neuronsen
dc.contributor.institutionSchool of Engineering and Technology
dc.contributor.institutionScience & Technology Research Institute
dc.contributor.institutionCentre for Engineering Research
dc.contributor.institutionMaterials and Structures
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Engineering and Technology
rioxxterms.versionofrecordhttps://doi.org/10.1002/tox.20586
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstyperestrictedAccess


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