Investigation of skin permeation using ATR-FTIR spectroscopic imaging and multivariate target factor analysis
Author
Mader, K. T.
Tetteh, J.
McAuley, W. J.
Lane, M. E.
Hadgraft, J.
Andanson, J. M.
Kazarian, S. G.
Attention
2299/6962
Abstract
ATR-FTIR spectroscopic imaging permeation experiments of a model formulation across stratum corneum (SC) were conducted to acquire further understanding of the mechanism of drug permeation. Quantitative iterative target transformation factor analysis (QITTFA) was used for the analysis of the complex and highly overlapping spectroscopic data generated.