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dc.contributor.authorKnabe, J.
dc.contributor.authorSchilstra, M.
dc.contributor.authorNehaniv, C.L.
dc.date.accessioned2011-11-21T12:01:10Z
dc.date.available2011-11-21T12:01:10Z
dc.date.issued2008
dc.identifier.citationKnabe , J , Schilstra , M & Nehaniv , C L 2008 , Evolution and morphogenesis of differentiated multicellular organisms: autonomously generated diffusion gradients for positional information . in Artificial Life XI : Procs of the 11th Int Conf on the Simulation and Synthesis of Living Systems. . MIT Press , pp. 321-328 .
dc.identifier.isbn978-0-262-75017-2
dc.identifier.otherPURE: 454684
dc.identifier.otherPURE UUID: c7cef43d-093d-42d6-ab9b-2a76aa3f226d
dc.identifier.otherdspace: 2299/2552
dc.identifier.otherScopus: 68349154220
dc.identifier.urihttp://hdl.handle.net/2299/7035
dc.descriptionOriginal paper can be found at: http://alifexi.alife.org/proceedings/
dc.description.abstractDevelopment is the powerful process involving a genome in the transformation from one egg cell to a multicellular organism with many cell types. The dividing cells manage to organize and assign themselves special, differentiated roles in a reliable manner, creating a spatio-temporal pattern and division of labor. This despite the fact that little positional information may be available to them initially to guide this patterning. Inspired by a model of developmental biologist L. Wolpert, we simulate this situation in an evolutionary setting where individuals have to grow into “French flag” patterns. The cells in our model exist in a 2-layer Potts model physical environment. Controlled by continuous genetic regulatory networks, identical for all cells of one individual, the cells can individually differ in parameters including target volume, shape, orientation, and diffusion. Intercellular communication is possible via secretion and sensing of diffusing morphogens. Evolved individuals growing from a single cell can develop the French flag pattern by setting up and maintaining asymmetric morphogen gradients – a behavior predicted by several theoretical models.en
dc.language.isoeng
dc.publisherMIT Press
dc.relation.ispartofArtificial Life XI
dc.rightsOpen
dc.titleEvolution and morphogenesis of differentiated multicellular organisms: autonomously generated diffusion gradients for positional informationen
dc.contributor.institutionSchool of Computer Science
dc.relation.schoolSchool of Computer Science
dc.description.versiontypeFinal Accepted Version
dcterms.dateAccepted2008
rioxxterms.versionAM
rioxxterms.typeOther
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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