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dc.contributor.authorDavenport, Andrew
dc.contributor.authorWellsted, D.
dc.contributor.authorPan Thames Renal Audit Peritoneal
dc.date.accessioned2012-01-03T10:01:11Z
dc.date.available2012-01-03T10:01:11Z
dc.date.issued2011
dc.identifier.citationDavenport , A , Wellsted , D & Pan Thames Renal Audit Peritoneal 2011 , ' Does antifungal prophylaxis with daily oral fluconazole reduce the risk of fungal peritonitis in peritoneal dialysis patients? The Pan Thames Renal Audit ' , Blood Purification , vol. 32 , no. 3 , pp. 181-185 . https://doi.org/10.1159/000328735
dc.identifier.issn0253-5068
dc.identifier.otherPURE: 347361
dc.identifier.otherPURE UUID: 828cc75d-935a-4141-9340-448cf35e824d
dc.identifier.otherWOS: 000293831400005
dc.identifier.otherScopus: 79960859351
dc.identifier.urihttp://hdl.handle.net/2299/7521
dc.descriptionOriginal article can be found at : http://content.karger.com/ Copyright Karger
dc.description.abstractBackground and Objectives: Fungal peritonitis increases the risk of transfer to haemodialysis and mortality. Methods: We audited the effect of co-prescription of daily oral fluconazole with antibiotics in the Pan Thames centres on fungal peritonitis. Results: We found 49 (1.5%) fungal peritonitis cases in 3,322 episodes of peritonitis. Two centres co-prescribed prophylactic fluconazole with antibiotics, with a fungal peritonitis rate of 0.0032/patient year, compared to 0.0099 from centres not using prophylaxis. However, centres using fungal prophylaxis had lower peritonitis rates of 0.036, compared to 0.05 for the other centres. Correcting for background peritonitis rates, there was no significant difference in the incidence of fungal peritonitis. Conclusions: In centres with a low incidence of fungal peritonitis, additional co-prescription of fluconazole with antibiotics appeared to reduce the risk of fungal peritonitis. However, variation in practice between centres is the main determinant of the observed incidence of fungal peritonitis rather than the use of antifungal prophylaxis.en
dc.language.isoeng
dc.relation.ispartofBlood Purification
dc.subjectPeritoneal dialysis
dc.subjectFungal peritonitis
dc.subjectProphylaxis
dc.subjectFluconazole
dc.titleDoes antifungal prophylaxis with daily oral fluconazole reduce the risk of fungal peritonitis in peritoneal dialysis patients? The Pan Thames Renal Auditen
dc.contributor.institutionApplied and Practice-based Research
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionDepartment of Psychology
dc.contributor.institutionPsychology
dc.contributor.institutionCentre for Lifespan and Chronic Illness Research
dc.contributor.institutionHealth and Clinical Psychology group
dc.contributor.institutionHealth Services and Medicine
dc.contributor.institutionStatistics and Methodology Research group
dc.contributor.institutionHealth Services Research group
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
rioxxterms.versionofrecordhttps://doi.org/10.1159/000328735
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstyperestrictedAccess


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