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dc.contributor.authorThompson, Colin J.
dc.contributor.authorDing, Caixia
dc.contributor.authorQu, Xiaozhong
dc.contributor.authorYang, Zhenzhong
dc.contributor.authorUchegbu, Ijeoma F.
dc.contributor.authorTetley, Laurence
dc.contributor.authorCheng, Woei Ping
dc.date.accessioned2012-01-03T12:01:07Z
dc.date.available2012-01-03T12:01:07Z
dc.date.issued2008-11
dc.identifier.citationThompson , C J , Ding , C , Qu , X , Yang , Z , Uchegbu , I F , Tetley , L & Cheng , W P 2008 , ' The effect of polymer architecture on the nano self-assemblies based on novel comb-shaped amphiphilic poly(allylamine) ' , Colloid and Polymer Science , vol. 286 , no. 13 , pp. 1511-1526 . https://doi.org/10.1007/s00396-008-1925-8
dc.identifier.issn0303-402X
dc.identifier.otherPURE: 383324
dc.identifier.otherPURE UUID: f9285594-a5fe-46ad-9d16-92a27abc661e
dc.identifier.otherWOS: 000259720600007
dc.identifier.otherScopus: 53549103019
dc.identifier.urihttp://hdl.handle.net/2299/7533
dc.description.abstractTwelve novel poly(allylamine) (PAA)-based, comb-shaped amphiphilic polymers have been developed. Hydrophobic groups of cetyl, palmitoyl and cholesteryl were randomly grafted to PAA and quaternisation was carried out on some modified polymers. Polymers were characterised using H-1 NMR, elemental analysis and differential scanning calorimetry. All polymers formed nano self-assemblies in the aqueous solution with a positive zeta potential and were able to encapsulate a hydrophobic agent, methyl orange, in the core. The critical aggregation concentration (CAC) and the microviscosity were found to be dependent on the polymer hydrophobicity. Being the most hydrophobic polymer, cholesteryl-grafted PAA had the lowest CAC (0.02 mg mL(-1)) and the highest microviscosity. They appeared to form dense nanoparticles and were transformed into novel nanostructures in the presence of free cholesterol. Palmitoyl-grafted polymers formed nanoparticles while cetyl-grafted polymers formed polymeric micelles. The flexibility of cetyl chains possibly resulted in the formation of multicore polymeric micelles.en
dc.format.extent16
dc.language.isoeng
dc.relation.ispartofColloid and Polymer Science
dc.subjectself-assembly
dc.subjectnanoparticles
dc.subjectmicelle
dc.subjectamphiphilic polymer
dc.subjectBLOCK-COPOLYMER MICELLES
dc.subjectDILUTE AQUEOUS-SOLUTIONS
dc.subjectDRUG-DELIVERY
dc.subjectDIBLOCK COPOLYMERS
dc.subjectMOLECULAR-WEIGHT
dc.subjectCHITOSAN
dc.subjectVESICLES
dc.subjectMICROVISCOSITY
dc.subjectDERIVATIVES
dc.subjectSOLUBILIZATION
dc.titleThe effect of polymer architecture on the nano self-assemblies based on novel comb-shaped amphiphilic poly(allylamine)en
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.description.statusPeer reviewed
dcterms.dateAccepted2008-11
rioxxterms.versionofrecordhttps://doi.org/10.1007/s00396-008-1925-8
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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