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dc.contributor.authorMurnane, Darragh
dc.contributor.authorMarriott, Christopher
dc.contributor.authorMartin, Gary P.
dc.date.accessioned2012-01-03T15:01:15Z
dc.date.available2012-01-03T15:01:15Z
dc.date.issued2008-05
dc.identifier.citationMurnane , D , Marriott , C & Martin , G P 2008 , ' Comparison of salmeterol xinafoate microparticle production by conventional and novel antisolvent crystallization ' , European Journal of Pharmaceutics and Biopharmaceutics , vol. 69 , no. 1 , pp. 94-105 . https://doi.org/10.1016/j.ejpb.2007.09.016
dc.identifier.issn0939-6411
dc.identifier.otherPURE: 398035
dc.identifier.otherPURE UUID: 2e53e74b-ed40-4172-8dc5-00fa9071d785
dc.identifier.otherWOS: 000255855100010
dc.identifier.otherScopus: 41549161049
dc.identifier.urihttp://hdl.handle.net/2299/7551
dc.description.abstractThe production of microparticles for inhalation has relied on jet-milling while the potential for crystallization of microparticles has remained underexplored until relatively recently. Aqueous antisolvent crystallization of salmeterol xinafoate (SX) from poly(ethylene glycol) (PEG) and other organic (co)solvent systems was compared in order to evaluate factors determining the resultant microparticle properties. SX was crystallized by the addition of water to solutions of SX in PEG 400, PEG 6000, propan-2-ol, acetone and methanol. Crystalline particles were characterized by laser diffraction sizing, scanning electron microscopy and differential scanning calorimetry; PEG-media were characterized by viscometry. Crystallization of SX from PEG 400 produced crystals that exhibited a narrower size distribution than those crystallized from other conventional organic solvents. SX crystallized from PEG 6000 demonstrated a smaller median particle size (D-(v,D-0.5) = 0.92 +/- 0.04 mu m) than PEG 400 crystallized SX (D-(v,D-0.5) = 4.50 +/- 0.61 mu m). Crystals produced from PEG 400 (Span = 2.49 +/- 0.10) possessed a narrower particle size distribution (PSD) than those produced from PEG 6000 (Span = 10.42 +/- 0.85). SX crystals displayed a plate-like habit with growth limited to two dimensions irrespective of the initial solvent employed. The importance of the rate of generation of SX supersaturation on the PSD was determined using HPLC analysis. DSC showed PEG-crystallized SX to be free from metastable crystal phases in contrast to SX crystallized from propan-2-ol. Crystallization of SX from PEG was shown to follow classical nucleation theory and the crystallization method represents a viable alternative to the use of conventional solvents for the production of microparticles. (C) 2007 Elsevier B.V. All rights reserved.en
dc.format.extent12
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Pharmaceutics and Biopharmaceutics
dc.subjectcrystallization
dc.subjectantisolvent micronization
dc.subjectpolymorphism
dc.subjectpoly(ethylene glycol)
dc.subjectsalmeterol xinafoate
dc.subjectmicroparticles
dc.subjectDRY POWDER INHALERS
dc.subjectPOLY(ETHYLENE GLYCOL)
dc.subjectCRYSTAL-GROWTH
dc.subjectPHARMACEUTICAL SYSTEMS
dc.subjectPOLYETHYLENE-GLYCOL
dc.subjectCHEMICAL-REACTIONS
dc.subjectPRECIPITATION
dc.subjectMIXTURES
dc.subjectBEHAVIOR
dc.subjectSOLVENT
dc.titleComparison of salmeterol xinafoate microparticle production by conventional and novel antisolvent crystallizationen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.ejpb.2007.09.016
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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