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dc.contributor.authorMurnane, Darragh
dc.contributor.authorMarriott, Christopher
dc.contributor.authorMartin, Gary P.
dc.date.accessioned2012-01-03T15:01:18Z
dc.date.available2012-01-03T15:01:18Z
dc.date.issued2008-09-01
dc.identifier.citationMurnane , D , Marriott , C & Martin , G P 2008 , ' Polymorphic control of inhalation microparticles prepared by crystallization ' International Journal of Pharmaceutics , vol. 361 , no. 1-2 , pp. 141-149 . https://doi.org/10.1016/j.ijpharm.2008.05.033
dc.identifier.issn0378-5173
dc.identifier.otherPURE: 398143
dc.identifier.otherPURE UUID: f40739cd-75ec-4b99-94c3-5b768226d3b7
dc.identifier.otherWOS: 000258803600021
dc.identifier.otherScopus: 47949124171
dc.identifier.urihttp://hdl.handle.net/2299/7553
dc.description.abstractMilling processes are known to cause polymorphic transition in enantiotropic systems and the micronization process employed to produce microparticles for inhalation formulations has been reported to result in solid-state damage. The aim of the current work was to investigate the polymorphism of salmeterol xinafoate (SX) following antisolvent micronization from poly(ethylene glycol) (PEG) solvents and compare this to the properties of SX conventionally crystallized and micronized. Powder X-ray diffraction revealed that SX crystallized predominantly as the SX form I polymorph following rapid precipitation from PEG solvents and cooling crystallization from propan-2-ol. Thermo-kinetic analysis using a modified Avrami-Erofe'ev equation was applied to differential scanning calorimetric thermographs of crystallized and micronized SX. The kinetic analysis revealed that SX crystallized from PEG solvents underwent significantly less or no re-crystallization of SX form II from the melt. A polymorphic transition was identified upon heating ball-milled SX, although the untreated material was resistant to such transformation. The thermal behaviour of SX crystallized from PEG solvents was consistent with a lower degree of crystal lattice disorder and higher enantiotropic purity than SX crystallized from propan-2-ol; the same was also true when comparing SX before and after micronization. (C) 2008 Elsevier B.V. All rights reserved.en
dc.format.extent9
dc.language.isoeng
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.subjectinhalation
dc.subjectaerosol
dc.subjectantisolvent micronization
dc.subjectpolymorphism
dc.subjectsalmeterol xinafoate
dc.subjectdifferential scanning calorimetry
dc.subjectthermal kinetic analysis
dc.subjectINVERSE GAS-CHROMATOGRAPHY
dc.subjectSUPERCRITICAL FLUIDS
dc.subjectMOLECULAR-CRYSTALS
dc.subjectSURFACE ENERGETICS
dc.subjectPHASE-CHANGE
dc.subjectKINETICS
dc.subjectTRANSFORMATIONS
dc.subjectQUANTIFICATION
dc.subjectTECHNOLOGY
dc.subjectNUCLEATION
dc.titlePolymorphic control of inhalation microparticles prepared by crystallizationen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.ijpharm.2008.05.033
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstyperestrictedAccess


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