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        Opto-Thermal Transient Emission Radiometry (OTTER) to image diffusion in nails in vivo

        Author
        Xiao, P.
        Zheng, X.
        Imhof, R. E.
        Hirata, K.
        McAuley, W. J.
        Mateus, R.
        Hadgraft, J.
        Lane, M. E.
        Attention
        2299/7566
        Abstract
        This work describes the first application of Opto-Thermal Transient Emission Radiometry (OTTER), an infrared remote sensing technique, to probe the extent to which solvents permeate the human nail in vivo. Decanol, glycerol and butyl acetate were selected as model solvents. After application of the solvents, individually, to human volunteers, OTTER was used to depth profile the solvents. The permeation rate of the solvents was ranked as glycerol > decanol > butyl acetate. It is possible that some of the butyl acetate may have evaporated during the experiment. The ability of decanol to extract lipids from biological tissue is also considered. These preliminary results demonstrate the potential of OTTER as a tool to identify optimal excipients with which to target drugs to the nail. (c) 2011 Elsevier B.V. All rights reserved.
        Publication date
        2011-03-15
        Published in
        International Journal of Pharmaceutics
        Published version
        https://doi.org/10.1016/j.ijpharm.2011.01.016
        Other links
        http://hdl.handle.net/2299/7566
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