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dc.contributor.authorXiao, P.
dc.contributor.authorZheng, X.
dc.contributor.authorImhof, R. E.
dc.contributor.authorHirata, K.
dc.contributor.authorMcAuley, W. J.
dc.contributor.authorMateus, R.
dc.contributor.authorHadgraft, J.
dc.contributor.authorLane, M. E.
dc.identifier.citationXiao , P , Zheng , X , Imhof , R E , Hirata , K , McAuley , W J , Mateus , R , Hadgraft , J & Lane , M E 2011 , ' Opto-Thermal Transient Emission Radiometry (OTTER) to image diffusion in nails in vivo ' , International Journal of Pharmaceutics , vol. 406 , no. 1-2 , pp. 111-113 .
dc.identifier.otherPURE: 437465
dc.identifier.otherPURE UUID: 04ddc998-838c-42dd-a01a-a18aca831c35
dc.identifier.otherWOS: 000288143200015
dc.identifier.otherScopus: 79951581226
dc.description.abstractThis work describes the first application of Opto-Thermal Transient Emission Radiometry (OTTER), an infrared remote sensing technique, to probe the extent to which solvents permeate the human nail in vivo. Decanol, glycerol and butyl acetate were selected as model solvents. After application of the solvents, individually, to human volunteers, OTTER was used to depth profile the solvents. The permeation rate of the solvents was ranked as glycerol > decanol > butyl acetate. It is possible that some of the butyl acetate may have evaporated during the experiment. The ability of decanol to extract lipids from biological tissue is also considered. These preliminary results demonstrate the potential of OTTER as a tool to identify optimal excipients with which to target drugs to the nail. (c) 2011 Elsevier B.V. All rights reserved.en
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.subjectOpto-Thermal Transient Emission
dc.subjectDepth profile
dc.titleOpto-Thermal Transient Emission Radiometry (OTTER) to image diffusion in nails in vivoen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionSkin and Nail Group
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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