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dc.contributor.authorDavies, M. J.
dc.contributor.authorJohnston, I.D.
dc.contributor.authorTan, C.K.L
dc.contributor.authorTracey, M.C.
dc.date.accessioned2012-04-16T13:58:00Z
dc.date.available2012-04-16T13:58:00Z
dc.date.issued2010
dc.identifier.citationDavies , M J , Johnston , I D , Tan , C K L & Tracey , M C 2010 , ' Whole blood pumping with a microthrottle pump ' , Biomicrofluidics , vol. 4 , no. 4 , 044112 . https://doi.org/10.1063/1.3528327
dc.identifier.issn1932-1058
dc.identifier.otherPURE: 112539
dc.identifier.otherPURE UUID: f719ec1a-59ec-4e97-b9f1-cc3c56c6d56d
dc.identifier.otherdspace: 2299/5489
dc.identifier.otherScopus: 80055094641
dc.identifier.urihttp://hdl.handle.net/2299/8327
dc.descriptionOriginal article can be found at: http://bmf.aip.org/ Copyright 2010 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics.
dc.description.abstractWe have previously reported that microthrottle pumps (MTPs) display the capacity to pump solid phase suspensions such as polystyrene beads which prove challenging to most microfluidic pumps. In this paper we report employing a linear microthrottle pump (LMTP) to pump whole, undiluted, anticoagulated, human venous blood at 200 μl min−1 with minimal erythrocyte lysis and no observed pump blockage. LMTPs are particularly well suited to particle suspension transport by virtue of their relatively unimpeded internal flow-path. Micropumping of whole blood represents a rigorous real-world test of cell suspension transport given blood’s high cell content by volume and erythrocytes’ relative fragility. A modification of the standard Drabkin method and its validation to spectrophotometrically quantify low levels of erythrocyte lysis by hemoglobin release is also reported. Erythrocyte lysis rates resulting from transport via LMTP are determined to be below one cell in 500 at a pumping rate of 102 μl min−1.en
dc.language.isoeng
dc.relation.ispartofBiomicrofluidics
dc.rights/dk/atira/pure/core/openaccesspermission/open
dc.subjectbiomedical equipment
dc.subjectbioMEMS
dc.subjectcellular transport
dc.subjectheomodynamics
dc.subjecthaemorheology
dc.subjectmicrofluidics
dc.subjectmicropumps
dc.titleWhole blood pumping with a microthrottle pumpen
dc.contributor.institutionSchool of Engineering and Technology
dc.contributor.institutionScience & Technology Research Institute
dc.contributor.institutionCentre for Engineering Research
dc.contributor.institutionMicrofluidics and Microengineering
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Engineering and Technology
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1063/1.3528327
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeclosedAccess


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