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dc.contributor.authorLiu, Fang
dc.contributor.authorBasit, A.W.
dc.identifier.citationLiu , F & Basit , A W 2010 , ' A paradigm shift in enteric coating : achieving rapid release in the proximal small intestine of man ' , Journal of Controlled Release , vol. 147 , no. 2 , pp. 242-245 .
dc.identifier.otherPURE: 815457
dc.identifier.otherPURE UUID: e06a4dfb-2eec-4353-b2e5-b44693eb53e7
dc.identifier.otherScopus: 77957021284
dc.description.abstractThe in vivo performance of a novel enteric double-coating technology designed to accelerate release in the proximal small intestine of humans was investigated. Tablet cores were coated with a double layer formulation consisting of an inner layer of EUDRAGIT® L 30 D-55 neutralised to pH 6.0 in the presence of 10% citric acid, and an outer layer of standard EUDRAGIT® L 30 D-55. A conventional single coating of EUDRAGIT® L 30 D-55 was also applied to tablets for comparison purposes, with the identical coating formulation and thickness (5 mg/cm2) as the outer layer of the double coating. Eight fasted volunteers received the double-coated and single-coated tablets in a two-way crossover study. The formulations were radiolabelled and followed by gamma scintigraphy; the disintegration times and positions were recorded. After leaving the stomach, tablets coated with the single-coating formulation showed a significant time delay before disintegration occurred in the mid to distal small intestine, with a mean disintegration time of 66 ± 22 min post gastric emptying. The double-coated tablets disintegrated earlier at 28 ± 6 min post gastric emptying with consistent disintegration in the proximal small intestine. The accelerated in vivo disintegration of the double-coating system can overcome the limitations of conventional enteric coating.en
dc.relation.ispartofJournal of Controlled Release
dc.titleA paradigm shift in enteric coating : achieving rapid release in the proximal small intestine of manen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.contributor.institutionBioadhesive Drug Delivery Group
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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