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dc.contributor.authorLiu, Fang
dc.contributor.authorLizio, R.
dc.contributor.authorMeier, C.
dc.contributor.authorPetereit, H.
dc.contributor.authorBlakey, P.
dc.contributor.authorBasit, A.W.
dc.date.accessioned2012-04-24T08:58:36Z
dc.date.available2012-04-24T08:58:36Z
dc.date.issued2009-01
dc.identifier.citationLiu , F , Lizio , R , Meier , C , Petereit , H , Blakey , P & Basit , A W 2009 , ' A novel concept in enteric coating : a double-coating system providing rapid drug release in the proximal small intestine ' , Journal of Controlled Release , vol. 133 , no. 2 , pp. 119-124 . https://doi.org/10.1016/j.jconrel.2008.09.083
dc.identifier.issn0168-3659
dc.identifier.otherPURE: 815631
dc.identifier.otherPURE UUID: 38c62934-6330-4275-9f5c-cb4bd14c4914
dc.identifier.otherScopus: 57349173031
dc.identifier.urihttp://hdl.handle.net/2299/8415
dc.description.abstractA novel double-coating enteric system was developed to accelerate drug release in conditions resembling the upper small intestine. The system comprises an inner coat (partially neutralised EUDRAGIT® L 30 D-55 and organic acid) and an outer coat (standard EUDRAGIT® L 30 D-55). Prednisolone tablets were coated with double layer formulations with inner coats neutralised to pH 5.6 in the presence of 10% citric acid or adipic acid. A conventional single coating was also applied for comparison purposes. There was no drug release from the single coated or double-coated tablets in 0.1M HCl for 2 h using USP II apparatus. The lag times of drug release in subsequent pH 5.6 phosphate buffer (to resemble the pH condition of the proximal small intestine) were 102, 42 and 28 min for the single coated, adipic acid and citric acid double-coated tablets respectively. The lag time for release from the double-coated tablets was further reduced to 5 min when the inner coat was neutralised to pH 6.0 in the presence of 10% citric acid. The rapid drug release from the double-coating system was associated with faster polymer dissolution rates compared to the single coating. The novel double-coated system has the potential to provide rapid drug release in the proximal small intestine, overcoming the limitations of conventional enteric coatingsen
dc.language.isoeng
dc.relation.ispartofJournal of Controlled Release
dc.titleA novel concept in enteric coating : a double-coating system providing rapid drug release in the proximal small intestineen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.contributor.institutionBioadhesive Drug Delivery Group
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=57349173031&partnerID=8YFLogxK
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted2009-01
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.jconrel.2008.09.083
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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