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dc.contributor.authorIravani, Mahmoud M.
dc.contributor.authorKruk, Z. L.
dc.date.accessioned2012-05-30T09:03:58Z
dc.date.available2012-05-30T09:03:58Z
dc.date.issued1995-03
dc.identifier.citationIravani , M M & Kruk , Z L 1995 , ' Effects of amphetamine on carrier-mediated and electrically stimulated dopamine release in slices of rat caudate-putamen abd nucleus-accumbens ' , Journal of Neurochemistry , vol. 64 , no. 3 , pp. 1161-1168 . https://doi.org/10.1046/j.1471-4159.1995.64031161.x
dc.identifier.issn0022-3042
dc.identifier.otherPURE: 736354
dc.identifier.otherPURE UUID: 74b4fa62-641f-4de8-ba61-5179073fd888
dc.identifier.otherWOS: A1995QG99500026
dc.identifier.otherScopus: 0028816855
dc.identifier.otherORCID: /0000-0002-4905-9682/work/32997613
dc.identifier.urihttp://hdl.handle.net/2299/8669
dc.description.abstractThe effects of (+)-amphetamine on carrier-mediated and electrically stimulated dopamine release were investigated using fast cyclic voltammetry in rat brain slices incorporating the nucleus accumbens, and in the caudate putamen. In the caudate putamen, dopamine release either increased with increasing frequency of local electrical stimulation (hot spots) or did not increase significantly (cold spots); dopamine release increased with increasing frequency of electrical stimulation in the nucleus accumbens. Local pressure application of(+)-amphetamine from a micropipette caused dopamine efflux at all sites examined, and this was not affected by sulpiride, indicating that efflux of dopamine caused by (+)amphetamine is not regulated by dopamine D-2 autoreceptors. (+)-Amphetamine reduced single-pulse electrically stimulated dopamine release at all sites; sulpiride reversed this decrease, indicating that endogenous dopamine released by (+)-amphetamine activates dopamine D-2 autoreceptors. In nucleus accumbens and hot spots, (+)-amphetamine did not affect 20-pulse 50-Hz-stimulated dopamine release, whereas in cold spots it potentiated 20-pulse 50-Hz-stimulated dopamine release. We conclude th at (+)-amphetamine modifies electrically stimulated dopamine release by uptake inhibition or by indirect activation of D-2 autoreceptors; the precise mechanism is determined by site and duration of electrical stimulation.en
dc.format.extent8
dc.language.isoeng
dc.relation.ispartofJournal of Neurochemistry
dc.subject(+)-AMPHETAMINE
dc.subjectFAST CYCLIC VOLTAMMETRY
dc.subjectBRAIN SLICES
dc.subjectCAUDATE PUTAMEN
dc.subjectNUCLEUS ACCUMBENS
dc.subjectHOT SPOTS
dc.subjectDOPAMINE D-2 AUTORECEPTORS
dc.subjectDOPAMINE RELEASE
dc.subjectBRAIN-SLICES
dc.subjectNEUROTRANSMITTER RELEASE
dc.subjectPRESYNAPTIC REGULATION
dc.subjectSTRIATUM
dc.subjectMATRIX
dc.subjectEFFLUX
dc.subjectAUTORECEPTORS
dc.subjectTRANSPORT
dc.subjectNOREPINEPHRINE
dc.titleEffects of amphetamine on carrier-mediated and electrically stimulated dopamine release in slices of rat caudate-putamen abd nucleus-accumbensen
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionPharmacology and Clinical Science Research
dc.contributor.institutionNeurodegenerative Diseases
dc.contributor.institutionAgriculture, Veterinary and Food Sciences
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1046/j.1471-4159.1995.64031161.x
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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