dc.contributor.author | Hill, K. | |
dc.contributor.author | Mann, L. | |
dc.contributor.author | Laws, K.R. | |
dc.contributor.author | Stephenson, C. M. E. | |
dc.contributor.author | Nimmo-Smith, I. | |
dc.contributor.author | McKenna, P. J. | |
dc.date.accessioned | 2007-10-09T16:00:25Z | |
dc.date.available | 2007-10-09T16:00:25Z | |
dc.date.issued | 2004 | |
dc.identifier.citation | Hill , K , Mann , L , Laws , K R , Stephenson , C M E , Nimmo-Smith , I & McKenna , P J 2004 , ' Hypofrontality in Schizophrenia. A meta-analysis of functional imaging studies ' , Acta Psychiatrica Scandinavica , vol. 110 , no. 4 , pp. 243-256 . https://doi.org/10.1111/j.1600-0447.2004.00376.x | |
dc.identifier.issn | 0001-690X | |
dc.identifier.other | dspace: 2299/873 | |
dc.identifier.other | ORCID: /0000-0002-5065-0867/work/124446438 | |
dc.identifier.uri | http://hdl.handle.net/2299/873 | |
dc.description | The definitive version is available at www.blackwell-synergy.com '--Copyright Blackwell Publishing | |
dc.description.abstract | Objective: Hypofrontality is not a well-replicated finding in schizophrenia either at rest or under conditions of task activation. Method: Studies comparing whole brain and frontal blood flow/ metabolism in schizophrenic patients and normal controls were pooled.Voxel-based studies were also combined to examine the pattern of prefrontal activation in schizophrenia. Results: Whole brain flow/metabolism was reduced in schizophrenia to only a small extent.Restin g and activation frontal flow/metabolism were both reduced with a medium effect size.Duration of illness significantly moderated resting hypofrontality, but the moderating effects of neuroleptic treatment were consistent with an influence on global flow/metabolism only.Pooling of voxel-based studies did not suggest an abnormal pattern of activation in schizophrenia. Conclusion: Meta-analysis supports resting hypofrontality in schizophrenia.Task-activated hypofrontality is also supported, but there is little from voxel-based studies to suggest that this is associated with an altered pattern of regional functional architecture. | en |
dc.format.extent | 431675 | |
dc.language.iso | eng | |
dc.relation.ispartof | Acta Psychiatrica Scandinavica | |
dc.subject | Psychology | |
dc.subject | fMRI | |
dc.subject | Frontal lobes | |
dc.title | Hypofrontality in Schizophrenia. A meta-analysis of functional imaging studies | en |
dc.contributor.institution | Department of Psychology | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.1111/j.1600-0447.2004.00376.x | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |