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dc.contributor.authorHill, K.
dc.contributor.authorMann, L.
dc.contributor.authorLaws, K.R.
dc.contributor.authorStephenson, C. M. E.
dc.contributor.authorNimmo-Smith, I.
dc.contributor.authorMcKenna, P. J.
dc.date.accessioned2007-10-09T16:00:25Z
dc.date.available2007-10-09T16:00:25Z
dc.date.issued2004
dc.identifier.citationHill , K , Mann , L , Laws , K R , Stephenson , C M E , Nimmo-Smith , I & McKenna , P J 2004 , ' Hypofrontality in Schizophrenia. A meta-analysis of functional imaging studies ' Acta Psychiatrica Scandinavica , vol. 110 , no. 4 , pp. 243-256 . https://doi.org/10.1111/j.1600-0447.2004.00376.x
dc.identifier.issn0001-690X
dc.identifier.otherPURE: 194883
dc.identifier.otherPURE UUID: 31681ea0-0823-48f3-83d4-402bf17b9d34
dc.identifier.otherdspace: 2299/873
dc.identifier.otherScopus: 4644291261
dc.identifier.urihttp://hdl.handle.net/2299/873
dc.descriptionThe definitive version is available at www.blackwell-synergy.com '--Copyright Blackwell Publishing
dc.description.abstractObjective: Hypofrontality is not a well-replicated finding in schizophrenia either at rest or under conditions of task activation. Method: Studies comparing whole brain and frontal blood flow/ metabolism in schizophrenic patients and normal controls were pooled.Voxel-based studies were also combined to examine the pattern of prefrontal activation in schizophrenia. Results: Whole brain flow/metabolism was reduced in schizophrenia to only a small extent.Restin g and activation frontal flow/metabolism were both reduced with a medium effect size.Duration of illness significantly moderated resting hypofrontality, but the moderating effects of neuroleptic treatment were consistent with an influence on global flow/metabolism only.Pooling of voxel-based studies did not suggest an abnormal pattern of activation in schizophrenia. Conclusion: Meta-analysis supports resting hypofrontality in schizophrenia.Task-activated hypofrontality is also supported, but there is little from voxel-based studies to suggest that this is associated with an altered pattern of regional functional architecture.en
dc.language.isoeng
dc.relation.ispartofActa Psychiatrica Scandinavica
dc.rights/dk/atira/pure/core/openaccesspermission/open
dc.subjectPsychology
dc.subjectfMRI
dc.subjectFrontal lobes
dc.titleHypofrontality in Schizophrenia. A meta-analysis of functional imaging studiesen
dc.contributor.institutionDepartment of Psychology
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1111/j.1600-0447.2004.00376.x
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstyperestrictedAccess


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