The free energy change of restricting a bond rotation in the binding of peptide analogues to vancomycin group antibiotics
Author
Gerhard, U.
Searle, M.S.
Williams, D.H.
Attention
2299/8941
Abstract
The adverse cost in free energy of restricting an internal bond rotation in the binding of the peptide ligands N-succinyl-D-alanine and N-fumaryl-D-alanine to the antibiotic Ristocetin A, has been estimated to be 3.7 ± 0.9 kJ mol per rotor by comparison of the difference in free energies of binding measured by UV spectrometry.