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Synthesis of conformationally constrained analogues of BRL32872 : Determination of stereochemistry and related pharmacological properties

dc.contributor.authorSouchet, M.
dc.contributor.authorForest, M.-C.
dc.contributor.authorCheval, B.
dc.contributor.authorRouanet, S.
dc.contributor.authorFaivre, J.-F.
dc.contributor.authorBril, A.
dc.contributor.authorGerhard, U.
dc.contributor.authorSmith, R.J.
dc.date.accessioned2012-08-23T14:00:55Z
dc.date.available2012-08-23T14:00:55Z
dc.date.issued1997-08-05
dc.identifier.citationSouchet , M , Forest , M-C , Cheval , B , Rouanet , S , Faivre , J-F , Bril , A , Gerhard , U & Smith , R J 1997 , ' Synthesis of conformationally constrained analogues of BRL32872 : Determination of stereochemistry and related pharmacological properties ' , Bioorganic and Medicinal Chemistry Letters , vol. 7 , no. 15 , pp. 1989-1994 . https://doi.org/10.1016/S0960-894X(97)00349-1
dc.identifier.issn0960-894X
dc.identifier.otherPURE: 940493
dc.identifier.otherPURE UUID: af6edefb-395d-49a4-8e94-2463b13603bc
dc.identifier.otherScopus: 0030743297
dc.identifier.urihttp://hdl.handle.net/2299/8947
dc.descriptionCopyright 2007 Elsevier B.V., All rights reserved.
dc.description.abstract2-Azabicyclo[2.2.2]octane derivatives have been used as conformationally constrained structure of BRL-32872, in order to investigate the effect of molecular flexibility towards class III and class IV antiarrhythmic properties. Extensive NMR studies allowed the determination of the configuration at C5. Stereoisomerism induces variability of biological profile.en
dc.format.extent6
dc.language.isoeng
dc.relation.ispartofBioorganic and Medicinal Chemistry Letters
dc.titleSynthesis of conformationally constrained analogues of BRL32872 : Determination of stereochemistry and related pharmacological propertiesen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=0030743297&partnerID=8YFLogxK
rioxxterms.versionofrecordhttps://doi.org/10.1016/S0960-894X(97)00349-1
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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