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dc.contributor.authorGibson, K.R.
dc.contributor.authorHitzel, L.
dc.contributor.authorMortishire-Smith, R.J.
dc.contributor.authorGerhard, U.
dc.contributor.authorJelley, R.A.
dc.contributor.authorReeve, A.J.
dc.contributor.authorRowley, M.
dc.contributor.authorNadin, A.
dc.contributor.authorOwens, A.P.
dc.identifier.citationGibson , K R , Hitzel , L , Mortishire-Smith , R J , Gerhard , U , Jelley , R A , Reeve , A J , Rowley , M , Nadin , A & Owens , A P 2002 , ' Synthesis and conformational dynamics of tricyclic pyridones containing a fused seven-membered ring ' , Journal of Organic Chemistry , vol. 67 , no. 26 , pp. 9354-9360 .
dc.identifier.otherPURE: 940614
dc.identifier.otherPURE UUID: 3fd440f5-5cdd-404e-8e94-de9201806280
dc.identifier.otherScopus: 0037184833
dc.descriptionMEDLINE® is the source for the MeSH terms of this document.
dc.description.abstractA new synthetic approach to tricyclic pyridones bearing a fused seven-membered ring is described. These compounds exhibit atropisomerism and exist in enantiomeric forms. Chiral HPLC separation of the enantiomers has allowed the rates of racemization to be measured and hence the free energy barrier for flipping the seven-membered ring to be deduced. Introduction of a further element of planar chirality leads to diastereomeric atropisomerism. The rate of interconversion of the diastereomers has been quantified by 2D EXSY NMR spectroscopy allowing a full description of the conformational dynamics of the system.en
dc.relation.ispartofJournal of Organic Chemistry
dc.titleSynthesis and conformational dynamics of tricyclic pyridones containing a fused seven-membered ringen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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