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dc.contributor.authorVan Niel, M.B.
dc.contributor.authorWilson, K.
dc.contributor.authorAdkins, C.H.
dc.contributor.authorAtack, J.R.
dc.contributor.authorCastro, J.L.
dc.contributor.authorClarke, D.E.
dc.contributor.authorFletcher, S.
dc.contributor.authorGerhard, U.
dc.contributor.authorMackey, M.M.
dc.contributor.authorMalpas, S.
dc.contributor.authorMaubach, K.
dc.contributor.authorNewman, R.
dc.contributor.authorO'Connor, D.
dc.contributor.authorPillai, G.V.
dc.contributor.authorSimpson, P.B.
dc.contributor.authorThomas, S.R.
dc.contributor.authorMacLeod, A.M.
dc.identifier.citationVan Niel , M B , Wilson , K , Adkins , C H , Atack , J R , Castro , J L , Clarke , D E , Fletcher , S , Gerhard , U , Mackey , M M , Malpas , S , Maubach , K , Newman , R , O'Connor , D , Pillai , G V , Simpson , P B , Thomas , S R & MacLeod , A M 2005 , ' A New Pyridazine Series of GABA A α5 Ligands ' , Journal of Medicinal Chemistry , vol. 48 , no. 19 , pp. 6004-6011 .
dc.identifier.otherPURE: 940958
dc.identifier.otherPURE UUID: d643ee7d-2d17-4868-bee8-c82d19032880
dc.identifier.otherScopus: 24944525688
dc.descriptionMEDLINE® is the source for the MeSH terms of this document.
dc.description.abstractScreening of the Merck compound collection identified 6 as an unusually simple, low molecular weight hit with moderate affinity for GABAA receptors. The structural novelty of 6, compared to our advanced series of GABAA α5 inverse agonists, made it an attractive molecule for further exploration. This paper will describe the evolution of 6 into a new series of ligands with nanomolar affinity and functional selectivity for GABAA α5 receptor subtypes.en
dc.relation.ispartofJournal of Medicinal Chemistry
dc.titleA New Pyridazine Series of GABAA α5 Ligandsen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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