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A New Pyridazine Series of GABAA α5 Ligands

dc.contributor.authorVan Niel, M.B.
dc.contributor.authorWilson, K.
dc.contributor.authorAdkins, C.H.
dc.contributor.authorAtack, J.R.
dc.contributor.authorCastro, J.L.
dc.contributor.authorClarke, D.E.
dc.contributor.authorFletcher, S.
dc.contributor.authorGerhard, U.
dc.contributor.authorMackey, M.M.
dc.contributor.authorMalpas, S.
dc.contributor.authorMaubach, K.
dc.contributor.authorNewman, R.
dc.contributor.authorO'Connor, D.
dc.contributor.authorPillai, G.V.
dc.contributor.authorSimpson, P.B.
dc.contributor.authorThomas, S.R.
dc.contributor.authorMacLeod, A.M.
dc.date.accessioned2012-08-23T14:01:06Z
dc.date.available2012-08-23T14:01:06Z
dc.date.issued2005-09-22
dc.identifier.citationVan Niel , M B , Wilson , K , Adkins , C H , Atack , J R , Castro , J L , Clarke , D E , Fletcher , S , Gerhard , U , Mackey , M M , Malpas , S , Maubach , K , Newman , R , O'Connor , D , Pillai , G V , Simpson , P B , Thomas , S R & MacLeod , A M 2005 , ' A New Pyridazine Series of GABA A α5 Ligands ' , Journal of Medicinal Chemistry , vol. 48 , no. 19 , pp. 6004-6011 . https://doi.org/10.1021/jm050249x
dc.identifier.issn0022-2623
dc.identifier.urihttp://hdl.handle.net/2299/8953
dc.descriptionMEDLINE® is the source for the MeSH terms of this document.
dc.description.abstractScreening of the Merck compound collection identified 6 as an unusually simple, low molecular weight hit with moderate affinity for GABAA receptors. The structural novelty of 6, compared to our advanced series of GABAA α5 inverse agonists, made it an attractive molecule for further exploration. This paper will describe the evolution of 6 into a new series of ligands with nanomolar affinity and functional selectivity for GABAA α5 receptor subtypes.en
dc.format.extent8
dc.language.isoeng
dc.relation.ispartofJournal of Medicinal Chemistry
dc.titleA New Pyridazine Series of GABAA α5 Ligandsen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=24944525688&partnerID=8YFLogxK
rioxxterms.versionofrecord10.1021/jm050249x
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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