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Identification of metabolites of a substance P (NK1 receptor) antagonist in rat hepatocytes and rat plasma

dc.contributor.authorHop, C.E.C.A.
dc.contributor.authorWang, Y.
dc.contributor.authorKumar, S.
dc.contributor.authorElipe, M.V.S.
dc.contributor.authorRaab, C.E.
dc.contributor.authorDean, D.C.
dc.contributor.authorPoon, G.K.
dc.contributor.authorKeohane, C.-A.
dc.contributor.authorStrauss, J.
dc.contributor.authorChiu, S.-H.L.
dc.contributor.authorCurtis, N.
dc.contributor.authorElliott, J.
dc.contributor.authorGerhard, U.
dc.contributor.authorLocker, K.
dc.contributor.authorMorrison, D.
dc.contributor.authorMortishire-Smith, R.
dc.contributor.authorWatt, A.P.
dc.contributor.authorEvans, D.C.
dc.date.accessioned2012-08-23T14:01:10Z
dc.date.available2012-08-23T14:01:10Z
dc.date.issued2002-01-01
dc.identifier.citationHop , C E C A , Wang , Y , Kumar , S , Elipe , M V S , Raab , C E , Dean , D C , Poon , G K , Keohane , C-A , Strauss , J , Chiu , S-HL , Curtis , N , Elliott , J , Gerhard , U , Locker , K , Morrison , D , Mortishire-Smith , R , Watt , A P & Evans , D C 2002 , ' Identification of metabolites of a substance P (NK1 receptor) antagonist in rat hepatocytes and rat plasma ' , Paper presented at Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics , Orlando , United States , 2/06/02 - 6/06/02 pp. 87-88 .
dc.identifier.citationconference
dc.identifier.otherPURE: 941079
dc.identifier.otherPURE UUID: 3ae02759-0928-4f0b-872c-5b3a3c7b439f
dc.identifier.otherScopus: 2442688006
dc.identifier.urihttp://hdl.handle.net/2299/8955
dc.descriptionCopyright 2008 Elsevier B.V., All rights reserved.
dc.description.abstractThe metabolism of a substance P (NK1 receptor) antagonist in rat hepatocytes and rat plasma was described. The samples were prepared for analysis by protein precipitation followed by centrifugation. It was shown that the radiochromatograms were remarkably different from that obtained with rat hepatocytes. The mass spectrometric data in the negative ion mode was obtained without TFA acid in the mobile phase. The keto acid structure was proposed based on the mass spectrometric and chromatographic data.en
dc.format.extent2
dc.language.isoeng
dc.relation.ispartof
dc.titleIdentification of metabolites of a substance P (NK1 receptor) antagonist in rat hepatocytes and rat plasmaen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=2442688006&partnerID=8YFLogxK
rioxxterms.typeOther
herts.preservation.rarelyaccessedtrue


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