dc.contributor.author | Liu, Zhaowei | |
dc.contributor.author | Zhang, Tao | |
dc.contributor.author | Ren, Guogang | |
dc.contributor.author | Yang, Zhuo | |
dc.date.accessioned | 2012-10-04T12:59:50Z | |
dc.date.available | 2012-10-04T12:59:50Z | |
dc.date.issued | 2012-06 | |
dc.identifier.citation | Liu , Z , Zhang , T , Ren , G & Yang , Z 2012 , ' Nano-Ag inhibiting action potential independent glutamatergic synaptic transmission but increasing excitability in rat CA1 pyramidal neurons ' , Nanotoxicology , vol. 6 , no. 4 , pp. 414-423 . https://doi.org/10.3109/17435390.2011.583996 | |
dc.identifier.issn | 1743-5390 | |
dc.identifier.other | ORCID: /0000-0001-8865-1526/work/32373263 | |
dc.identifier.uri | http://hdl.handle.net/2299/9051 | |
dc.description.abstract | The aim of this study was to investigate the actions of silver nanoparticles (nano-Ag) on glutamatergic synaptic transmission and excitability in hippocampal CA1 pyramidal neurons with whole cell patch technique. The amplitude of miniature excitatory postsynaptic currents (mEPSCs) was inhibited by silver nano-particles (nano-Ag) (10(-5) g/ml and 10(-4) g/ml), but the amplitude and frequency of spontaneous excitatory postsynaptic currents (sEPSCs) were increased by nano-Ag treatment (10(-5) g/ml and 10(-4) g/ml). Furthermore, nano-Ag (10(-5) g/ml and 10(-4) g/ml) increased the spontaneous network activity. These results provide further insights into the underlying mechanisms responsible for the effects of nano-Ag on central nervous system (CNS). | en |
dc.format.extent | 10 | |
dc.format.extent | 423866 | |
dc.language.iso | eng | |
dc.relation.ispartof | Nanotoxicology | |
dc.title | Nano-Ag inhibiting action potential independent glutamatergic synaptic transmission but increasing excitability in rat CA1 pyramidal neurons | en |
dc.contributor.institution | School of Engineering and Technology | |
dc.contributor.institution | Science & Technology Research Institute | |
dc.contributor.institution | Centre for Engineering Research | |
dc.contributor.institution | Materials and Structures | |
dc.description.status | Peer reviewed | |
dc.date.embargoedUntil | 2013-07-01 | |
rioxxterms.versionofrecord | 10.3109/17435390.2011.583996 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |