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dc.contributor.authorLiu, Zhaowei
dc.contributor.authorZhang, Tao
dc.contributor.authorRen, Guogang
dc.contributor.authorYang, Zhuo
dc.date.accessioned2012-10-04T12:59:50Z
dc.date.available2012-10-04T12:59:50Z
dc.date.issued2012-06
dc.identifier.citationLiu , Z , Zhang , T , Ren , G & Yang , Z 2012 , ' Nano-Ag inhibiting action potential independent glutamatergic synaptic transmission but increasing excitability in rat CA1 pyramidal neurons ' , Nanotoxicology , vol. 6 , no. 4 , pp. 414-423 . https://doi.org/10.3109/17435390.2011.583996
dc.identifier.issn1743-5390
dc.identifier.otherPURE: 949524
dc.identifier.otherPURE UUID: 2e054856-9282-4d9c-8279-6c8f11020787
dc.identifier.otherWOS: 000303830500007
dc.identifier.otherScopus: 84860832891
dc.identifier.otherORCID: /0000-0001-8865-1526/work/32373263
dc.identifier.urihttp://hdl.handle.net/2299/9051
dc.description.abstractThe aim of this study was to investigate the actions of silver nanoparticles (nano-Ag) on glutamatergic synaptic transmission and excitability in hippocampal CA1 pyramidal neurons with whole cell patch technique. The amplitude of miniature excitatory postsynaptic currents (mEPSCs) was inhibited by silver nano-particles (nano-Ag) (10(-5) g/ml and 10(-4) g/ml), but the amplitude and frequency of spontaneous excitatory postsynaptic currents (sEPSCs) were increased by nano-Ag treatment (10(-5) g/ml and 10(-4) g/ml). Furthermore, nano-Ag (10(-5) g/ml and 10(-4) g/ml) increased the spontaneous network activity. These results provide further insights into the underlying mechanisms responsible for the effects of nano-Ag on central nervous system (CNS).en
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofNanotoxicology
dc.rightsEmbargoed
dc.titleNano-Ag inhibiting action potential independent glutamatergic synaptic transmission but increasing excitability in rat CA1 pyramidal neuronsen
dc.contributor.institutionSchool of Engineering and Technology
dc.contributor.institutionScience & Technology Research Institute
dc.contributor.institutionCentre for Engineering Research
dc.contributor.institutionMaterials and Structures
dc.description.statusPeer reviewed
dc.date.embargoedUntil2013-07-01
dc.description.versiontypeFinal Accepted Version
dcterms.dateAccepted2012-06
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.3109/17435390.2011.583996
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeEmbargoed


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