Show simple item record

dc.contributor.authorHoskins, C.
dc.contributor.authorThoo-Lin, P.K.
dc.contributor.authorCheng, W.P.
dc.date.accessioned2012-10-04T14:59:36Z
dc.date.available2012-10-04T14:59:36Z
dc.date.issued2012-01-01
dc.identifier.citationHoskins , C , Thoo-Lin , P K & Cheng , W P 2012 , ' A review on comb-shaped amphiphilic polymers for hydrophobic drug solubilization ' , Therapeutic Delivery , vol. 3 , no. 1 , pp. 59-79 . https://doi.org/10.4155/tde.11.130
dc.identifier.issn2041-5990
dc.identifier.otherPURE: 533955
dc.identifier.otherPURE UUID: e0cf3aa9-492b-4543-a435-29d92f4cb665
dc.identifier.otherScopus: 84155175847
dc.identifier.urihttp://hdl.handle.net/2299/9058
dc.descriptionCopyright 2011 Elsevier B.V., All rights reserved.
dc.description.abstractComb-shaped amphiphilic polymers are rapidly emerging as an alternative approach to amphiphilic block copolymers for hydrophobic drug solubilization. These polymers consist of a homopolymer or copolymer backbone to which hydrophobic and hydrophilic pendant groups can be grafted resulting in a comb-like architecture. The hydrophobic pendants may consist of homopolymers, copolymers and other low-molecular weight hydrophobic structures. In this review, we focus on hydrophobically modified preformed homopolymers. Comb-shaped amphiphilic polymers possess reduced critical aggregation concentration values compared with traditional surfactant micelles indicating increased stability with decreased disruption experienced on dilution. They have been fabricated with diverse architectures and multifunctional properties such as site-specific targeting and external stimuli-responsive nature. The application of comb-shaped amphiphilic polymers is expanding; here we report on the progress achieved so far in hydrophobic drug solubilization for both intravenous and oral deliveryen
dc.format.extent21
dc.language.isoeng
dc.relation.ispartofTherapeutic Delivery
dc.titleA review on comb-shaped amphiphilic polymers for hydrophobic drug solubilizationen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionNanopharmaceutics
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.description.statusPeer reviewed
dc.date.embargoedUntil2013-01-01
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84155175847&partnerID=8YFLogxK
rioxxterms.versionAM
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.4155/tde.11.130
rioxxterms.typeJournal Article/Review


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record