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dc.contributor.authorXie, Yongling
dc.contributor.authorWang, Yiyi
dc.contributor.authorZhang, Tao
dc.contributor.authorRen, Guogang
dc.contributor.authorYang, Zhuo
dc.date.accessioned2012-10-04T14:59:49Z
dc.date.available2012-10-04T14:59:49Z
dc.date.issued2012-02-03
dc.identifier.citationXie , Y , Wang , Y , Zhang , T , Ren , G & Yang , Z 2012 , ' Effects of nanoparticle zinc oxide on spatial cognition and synaptic plasticity in mice with depressive-like behaviors ' , Journal of Biomedical Science , vol. 19 , 14 . https://doi.org/10.1186/1423-0127-19-14
dc.identifier.issn1021-7770
dc.identifier.otherPURE: 958853
dc.identifier.otherPURE UUID: f8f6b66a-e006-45c4-a681-130edea7a3fa
dc.identifier.otherWOS: 000302095200001
dc.identifier.otherScopus: 84856474977
dc.identifier.otherORCID: /0000-0001-8865-1526/work/32373268
dc.identifier.urihttp://hdl.handle.net/2299/9064
dc.description.abstractBackground: Nanomaterials, as a new kind of materials, have been greatly applied in different fields due to their special properties. With the industrialization of nanostructured materials and increasing public exposure, the biosafety and potential influences on central nervous system (CNS) have received more attention. Nanosized zinc oxide (nanoZnO) was suggested to up-regulate neuronal excitability and to induce glutamate release in vitro. Therefore, we hypothesized nanoparticles of nanoZnO may lead to changes in balance of neurotransmitter or neuronal excitability of CNS. This study was to investigate if there were effects of nanoZnO on animal model of depression. Methods: Male Swiss mice were given lipopolysaccharides (LPS, 100 mu g/kg, 100 mu g/ml, every other day, 8 times, i.p.) from weaning to induce depressive-like behaviors. NanoZnO (5.6 mg/kg, 5.6 mg/ml, every other day, 8 times, i.p.) was given as the interaction. The mouse model was characterized using the methods of open field test, tail suspension test and forced swim test. Furthermore, the spatial memory was evaluated using Morris water maze (MWM) and the synaptic plasticity was assessed by measuring the long-term potentiation (LTP) in the perforant pathway (PP) to dentate gyrus (DG) in vivo. Results: Results indicated that model mice showed disrupted spatial memory and LTP after LPS injections and the behavioral and electrophysiological improvements after nanoZnO treatment. Conclusion: Data suggested that nanoZnO may play some roles in CNS of mental disorders, which could provide some useful direction on the new drug exploring and clinical researches.en
dc.format.extent11
dc.language.isoeng
dc.relation.ispartofJournal of Biomedical Science
dc.titleEffects of nanoparticle zinc oxide on spatial cognition and synaptic plasticity in mice with depressive-like behaviorsen
dc.contributor.institutionSchool of Engineering and Technology
dc.contributor.institutionScience & Technology Research Institute
dc.contributor.institutionCentre for Engineering Research
dc.contributor.institutionMaterials and Structures
dc.description.statusPeer reviewed
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1186/1423-0127-19-14
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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