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dc.contributor.authorGaya, A.M.
dc.contributor.authorDaley, F.
dc.contributor.authorTaylor, N. J.
dc.contributor.authorTozer, G.
dc.contributor.authorQureshi, U
dc.contributor.authorPadhani, A.
dc.contributor.authorPedley, R. Barbara
dc.contributor.authorBegent, R
dc.contributor.authorWellsted, D.
dc.contributor.authorStirling, J J
dc.contributor.authorRustin, G
dc.date.accessioned2012-12-04T16:00:00Z
dc.date.available2012-12-04T16:00:00Z
dc.date.issued2008
dc.identifier.citationGaya , A M , Daley , F , Taylor , N J , Tozer , G , Qureshi , U , Padhani , A , Pedley , R B , Begent , R , Wellsted , D , Stirling , J J & Rustin , G 2008 , ' Relationship between human tumour angiogenic profile and combretastatin-induced vascular shutdown : an exploratory study ' , British Journal of Cancer , vol. 99 , no. 2 , pp. 321-6 . https://doi.org/10.1038/sj.bjc.6604426
dc.identifier.issn1532-1827
dc.identifier.otherPURE: 1022368
dc.identifier.otherPURE UUID: 1a8942ca-b9d2-4006-9ef8-f4d1b947bbb1
dc.identifier.otherPubMed: 18612312
dc.identifier.otherScopus: 48249103089
dc.identifier.urihttp://hdl.handle.net/2299/9303
dc.description.abstractCombretastatin-A4-phosphate (CA4P) acts most effectively against immature tumour vasculature. We investigated whether histological angiogenic profile can explain the differential sensitivity of human tumours to CA4P, by correlating the kinetic changes demonstrated by dynamic MRI (DCE-MRI) in response to CA4P, with tumour immunohistochemical angiogenic markers. Tissue was received from 24 patients (mean age 59, range 32-73, 18 women, 6 men). An angiogenic profile was performed using standard immunohistochemical techniques. Dynamic MRI data were obtained for the same patients before and 4 h after CA4P. Three patients showed a statistically significant fall in K(trans) following CA4P, and one a statistically significant fall in IAUGC(60). No statistically significant correlations were seen between the continuous or categorical variables and the DCE-MRI kinetic parameters other than between ang-2 and K(trans) (P=0.044). In conclusion, we found no strong relationships between changes in DCE-MRI kinetic variables following CA4P and the immunohistochemical angiogenic profile.en
dc.format.extent6
dc.language.isoeng
dc.relation.ispartofBritish Journal of Cancer
dc.rightsOpen
dc.titleRelationship between human tumour angiogenic profile and combretastatin-induced vascular shutdown : an exploratory studyen
dc.contributor.institutionApplied and Practice-based Research
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionDepartment of Psychology
dc.contributor.institutionPsychology
dc.contributor.institutionCentre for Lifespan and Chronic Illness Research
dc.contributor.institutionHealth and Clinical Psychology group
dc.contributor.institutionHealth Services and Medicine
dc.contributor.institutionStatistics and Methodology Research group
dc.contributor.institutionHealth Services Research group
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2008
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1038/sj.bjc.6604426
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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