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dc.contributor.authorSchifano, Fabrizio
dc.contributor.authorD'Offizi, S.
dc.contributor.authorPiccione, M.
dc.contributor.authorCorazza, Ornella
dc.contributor.authorDeluca, P.
dc.contributor.authorDavey, Z.
dc.contributor.authordi Melchiorre, G.
dc.contributor.authorDiFuria, L.
dc.contributor.authorFarre, M.
dc.contributor.authorFlesland, L.
dc.contributor.authorMannonen, M.
dc.contributor.authorMajava, A.
dc.contributor.authorPagani, S.
dc.contributor.authorPeltoniemi, T.
dc.contributor.authorSiemann, H.
dc.contributor.authorSkutle, A.
dc.contributor.authorTorrens, M.
dc.contributor.authorPezzolesi, C.
dc.contributor.authorvan der Kreeft, P.
dc.contributor.authorScherbaum, N.
dc.date.accessioned2012-12-06T15:29:44Z
dc.date.available2012-12-06T15:29:44Z
dc.date.issued2011
dc.identifier.citationSchifano , F , D'Offizi , S , Piccione , M , Corazza , O , Deluca , P , Davey , Z , di Melchiorre , G , DiFuria , L , Farre , M , Flesland , L , Mannonen , M , Majava , A , Pagani , S , Peltoniemi , T , Siemann , H , Skutle , A , Torrens , M , Pezzolesi , C , van der Kreeft , P & Scherbaum , N 2011 , ' Is there a recreational misuse potential for Pregabalin? Analysis of anecdotal online reports in comparison with related Gabapentin and Clonazepam data ' , Psychotherapy and Psychosomatics , vol. 80 , no. 2 , pp. 118-122 . https://doi.org/10.1159/000321079
dc.identifier.issn0033-3190
dc.identifier.otherPURE: 183044
dc.identifier.otherPURE UUID: ec981186-7cd5-4063-aab7-0ed099d693dd
dc.identifier.otherdspace: 2299/5529
dc.identifier.otherScopus: 78650866015
dc.identifier.urihttp://hdl.handle.net/2299/9328
dc.descriptionOriginal article can be found at: http://content.karger.com/ Copyright Karger.
dc.description.abstractBackground: Although pregabalin abuse potential is reportedly low, online data related to its recreational misuse potential have recently been identified. We aimed here at formally analysing pregabalin misuse web reports and comparing these with data pertaining to similar drugs, e.g. gabapentin and clonazepam, for which an abuse potential has already been identified. Methods: An 8-language analysis of the online information on pregabalin acquisition/misuse was carried out. An initial sample of 203 websites was considered and 108 relevant websites were monitored on a regular basis. To obtain material relating to gabapentin and clonazepam, an English-language search was carried out and 32 relevant websites were examined. Results: Misuse of pregabalin, which is commonly offered for sale online, was allegedly associated with sedative and/or psychedelic effects. This was associated with both higher dosages than clinically advised and idiosyncratic (i.e.: IV, rectal, intranasal) drug intake modalities. Although perceived as less powerful than pregabalin, gabapentin misuse was associated with similar sedative/psychedelic effects. Clonazepam allegedly induced either sedation or stimulation, depending on the dosage. Conclusions: Pregabalin experimenters might be profiled as individuals with a history of recreational polydrug misuse. Pregabalin misuse might be facilitated by easy online accessibility; potency; and peculiar, including anxiolytic, psychoactive effects. Physicians should carefully evaluate patients for history of drug abuse and observe them for signs of pregabalin/gabapentin/clonazepam misuse.en
dc.language.isoeng
dc.relation.ispartofPsychotherapy and Psychosomatics
dc.rightsOpen
dc.subjectneuropathic pain
dc.subjectabuse liability
dc.subjectdrug
dc.subjectbenzodiazepines
dc.subjectwithdrawal
dc.subjectdependence
dc.subjectdiscontinuation
dc.subjectdisorders
dc.subjectinternet
dc.subjectproject
dc.titleIs there a recreational misuse potential for Pregabalin? : Analysis of anecdotal online reports in comparison with related Gabapentin and Clonazepam dataen
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionCentre for Clinical Practice, Safe Medicines and Drug Misuse Research
dc.contributor.institutionPatient and Medicines Safety
dc.contributor.institutionPrescription and Illicit Drug Misuse
dc.contributor.institutionCentre for Postgraduate Medicine
dc.contributor.institutionPostgraduate Medicine
dc.contributor.institutionHealth Services and Medicine
dc.contributor.institutionPublic Health
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=78650866015&partnerID=8YFLogxK
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted2011
rioxxterms.versionofrecordhttps://doi.org/10.1159/000321079
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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