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dc.contributor.authorVargas-Reus, Miguel
dc.contributor.authorMemarzadeh, Kaveh
dc.contributor.authorHuang, Jie
dc.contributor.authorRen, Guogang
dc.contributor.authorAllaker, Robert
dc.date.accessioned2012-12-06T15:59:52Z
dc.date.available2012-12-06T15:59:52Z
dc.date.issued2012-08
dc.identifier.citationVargas-Reus , M , Memarzadeh , K , Huang , J , Ren , G & Allaker , R 2012 , ' Antimicrobial activity of nanoparticulate metal oxides against peri-implantitis pathogens ' , International Journal of Antimicrobial Agents , vol. 40 , no. 2 , pp. 135-139 . https://doi.org/10.1016/j.ijantimicag.2012.04.012
dc.identifier.otherPURE: 914253
dc.identifier.otherPURE UUID: ad465cb9-37f6-42e4-97a5-367b6cde2be5
dc.identifier.otherWOS: 000306663800007
dc.identifier.otherScopus: 84864286384
dc.identifier.otherORCID: /0000-0001-8865-1526/work/32373262
dc.identifier.urihttp://hdl.handle.net/2299/9331
dc.description.abstractDental plaque accumulation may result in peri-implantitis, an inflammatory process causing loss of supporting bone that may lead to dental implant failure. The antimicrobial activities of six metal and metal oxide nanoparticles and two of their composites against bacterial pathogens associated with peri-implantitis were examined under anaerobic conditions. The activities of nanoparticles of silver (Ag), cuprous oxide (Cu2O), cupric oxide (CuO), zinc oxide (ZnO), titanium dioxide (TiO2), tungsten oxide (WO3 ), Ag + CuO composite and Ag + ZnO composite were assessed by minimum inhibitory (bacte- riostatic) concentration (MIC) and minimum bactericidal concentration (MBC) determination against Prevotella intermedia, Porphyromonas gingivalis, Fusobacterium nucleatum and Aggregatibacter actino- mycetemcomitans. Time–kill assays were carried out to examine the dynamics of the antimicrobial activity with ZnO nanoparticles. MIC and MBC values were in the range of <100ﰀg/mL to 2500ﰀg/mL and <100 ﰀg/mL to >2500 ﰀg/mL, respectively. The activity of the nanoparticles tested in descending order was Ag > Ag + CuO > Cu2O > CuO > Ag + ZnO > ZnO > TiO2 > WO3. Time–kill assays with ZnO demonstrated a significant decrease in growth of all species tested within 4 h, reaching 100% within 2 h for P. gingivalis and within 3 h for F. nucleatum and P. intermedia. Coating titanium surfaces of dental and orthopaedic implants with antimicrobial nanoparticles should lead to an increased rate of implant success.en
dc.format.extent5
dc.language.isoeng
dc.relation.ispartofInternational Journal of Antimicrobial Agents
dc.subjectPeri-implantitis
dc.subjectNanoparticles
dc.subjectMetal oxide
dc.subjectAntimicrobials
dc.subjectESCHERICHIA-COLI
dc.subjectSILVER NANOPARTICLES
dc.subjectANTIBACTERIAL ACTIVITY
dc.subjectSTAPHYLOCOCCUS-AUREUS
dc.subjectPHOTOCATALYTIC OXIDATION
dc.subjectINACTIVATION
dc.subjectMECHANISM
dc.subjectCOPPER
dc.subjectIONS
dc.subjectCARE
dc.titleAntimicrobial activity of nanoparticulate metal oxides against peri-implantitis pathogensen
dc.contributor.institutionSchool of Engineering and Technology
dc.contributor.institutionScience & Technology Research Institute
dc.contributor.institutionCentre for Engineering Research
dc.contributor.institutionMaterials and Structures
dc.description.statusPeer reviewed
dcterms.dateAccepted2012-08
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.ijantimicag.2012.04.012
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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