dc.contributor.author | Khengar, Rajeshree H. | |
dc.contributor.author | Brown, Marc | |
dc.contributor.author | Turner, Rob B. | |
dc.contributor.author | Traynor, M.J. | |
dc.contributor.author | Holt, Katherine B. | |
dc.contributor.author | Jones, Stuart A. | |
dc.date.accessioned | 2012-12-17T14:29:38Z | |
dc.date.available | 2012-12-17T14:29:38Z | |
dc.date.issued | 2010-09-01 | |
dc.identifier.citation | Khengar , R H , Brown , M , Turner , R B , Traynor , M J , Holt , K B & Jones , S A 2010 , ' Free radical facilitated damage of ungual keratin ' , Free Radical Biology and Medicine , vol. 49 , no. 5 , pp. 865-871 . https://doi.org/10.1016/j.freeradbiomed.2010.06.013 | |
dc.identifier.issn | 0891-5849 | |
dc.identifier.other | dspace: 2299/4809 | |
dc.identifier.other | ORCID: /0000-0001-7332-0011/work/32634800 | |
dc.identifier.uri | http://hdl.handle.net/2299/9420 | |
dc.description | Original article can be found at: http://www.sciencedirect.com/science/journal/08915849 Copyright Elsevier Inc. | |
dc.description.abstract | Thioglycolic acid (TA) and urea hydrogen peroxide (urea H2O2) are thought to disrupt alpha-keratin disulfide links in the nail However, optimal clinical use of these agents to improve the treatment of nail disorders is currently hindered by a lack of fundamental data to support their mechanism of action The aim of this study was to investigate how the redox environment of ungual keratin. when manipulated by TA and urea H2O2. influenced the properties of the nail barrier Potentiometric and voltammetric measurements demonstrated that urea H2O2 obeyed the Nernst equation for a proton coupled one-electron transfer redox process while TA underwent a series of redox reactions that was complicated by electrode adsorption and duller formation. The functional studies demonstrated that nail permeability, measured through TBF, penetration (38 51 +/- 10 94 mu g/cm(2)/ h) and nail swelling (244 10 +/- 14 99% weight increase), was greatest when relatively low concentrations of the thiolate Ion were present in the applied solution Limiting the thiolate ion to low levels in the solution retards thiolate dimerisation and generates thryl free radicals It appeared that this free radical generation was fundamental in facilitating the redox-mediated keratin disruption of the Lingual membrane (C) 2010 Elsevier Inc All rights reserved | en |
dc.format.extent | 7 | |
dc.format.extent | 255813 | |
dc.language.iso | eng | |
dc.relation.ispartof | Free Radical Biology and Medicine | |
dc.subject | Nail | |
dc.subject | Onychomycosis | |
dc.subject | Ungual | |
dc.subject | Thioglycolic acid | |
dc.subject | Disulfide | |
dc.subject | Redox | |
dc.subject | ELECTROCATALYTIC OXIDATION | |
dc.subject | COBALT PHTHALOCYANINE | |
dc.subject | DISULFIDE BONDS | |
dc.subject | HUMAN NAIL | |
dc.subject | ELECTRODE | |
dc.subject | HAIR | |
dc.subject | PERMEABILITY | |
dc.subject | BARRIER | |
dc.subject | ACID | |
dc.title | Free radical facilitated damage of ungual keratin | en |
dc.contributor.institution | Health & Human Sciences Research Institute | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Department of Pharmacy | |
dc.contributor.institution | Centre for Research into Topical Drug Delivery and Toxicology | |
dc.contributor.institution | Pharmaceutics | |
dc.contributor.institution | Skin and Nail Group | |
dc.contributor.institution | Airway Group | |
dc.contributor.institution | Bioadhesive Drug Delivery Group | |
dc.contributor.institution | Nanopharmaceutics | |
dc.contributor.institution | Pharmaceutical Analysis and Product Characterisation | |
dc.contributor.institution | Toxicology | |
dc.description.status | Peer reviewed | |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=77955093407&partnerID=8YFLogxK | |
rioxxterms.versionofrecord | 10.1016/j.freeradbiomed.2010.06.013 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |