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dc.contributor.authorKhengar, Rajeshree H.
dc.contributor.authorBrown, Marc
dc.contributor.authorTurner, Rob B.
dc.contributor.authorTraynor, M.J.
dc.contributor.authorHolt, Katherine B.
dc.contributor.authorJones, Stuart A.
dc.date.accessioned2012-12-17T14:29:38Z
dc.date.available2012-12-17T14:29:38Z
dc.date.issued2010-09-01
dc.identifier.citationKhengar , R H , Brown , M , Turner , R B , Traynor , M J , Holt , K B & Jones , S A 2010 , ' Free radical facilitated damage of ungual keratin ' , Free Radical Biology and Medicine , vol. 49 , no. 5 , pp. 865-871 . https://doi.org/10.1016/j.freeradbiomed.2010.06.013
dc.identifier.issn0891-5849
dc.identifier.otherPURE: 185598
dc.identifier.otherPURE UUID: 541a95b8-a772-4757-b1da-716b33ae91a1
dc.identifier.otherdspace: 2299/4809
dc.identifier.otherWOS: 000280745900020
dc.identifier.otherScopus: 77955093407
dc.identifier.otherORCID: /0000-0001-7332-0011/work/32634800
dc.identifier.urihttp://hdl.handle.net/2299/9420
dc.descriptionOriginal article can be found at: http://www.sciencedirect.com/science/journal/08915849 Copyright Elsevier Inc.
dc.description.abstractThioglycolic acid (TA) and urea hydrogen peroxide (urea H2O2) are thought to disrupt alpha-keratin disulfide links in the nail However, optimal clinical use of these agents to improve the treatment of nail disorders is currently hindered by a lack of fundamental data to support their mechanism of action The aim of this study was to investigate how the redox environment of ungual keratin. when manipulated by TA and urea H2O2. influenced the properties of the nail barrier Potentiometric and voltammetric measurements demonstrated that urea H2O2 obeyed the Nernst equation for a proton coupled one-electron transfer redox process while TA underwent a series of redox reactions that was complicated by electrode adsorption and duller formation. The functional studies demonstrated that nail permeability, measured through TBF, penetration (38 51 +/- 10 94 mu g/cm(2)/ h) and nail swelling (244 10 +/- 14 99% weight increase), was greatest when relatively low concentrations of the thiolate Ion were present in the applied solution Limiting the thiolate ion to low levels in the solution retards thiolate dimerisation and generates thryl free radicals It appeared that this free radical generation was fundamental in facilitating the redox-mediated keratin disruption of the Lingual membrane (C) 2010 Elsevier Inc All rights reserveden
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofFree Radical Biology and Medicine
dc.subjectNail
dc.subjectOnychomycosis
dc.subjectUngual
dc.subjectThioglycolic acid
dc.subjectDisulfide
dc.subjectRedox
dc.subjectELECTROCATALYTIC OXIDATION
dc.subjectCOBALT PHTHALOCYANINE
dc.subjectDISULFIDE BONDS
dc.subjectHUMAN NAIL
dc.subjectELECTRODE
dc.subjectHAIR
dc.subjectPERMEABILITY
dc.subjectBARRIER
dc.subjectACID
dc.titleFree radical facilitated damage of ungual keratinen
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionSkin and Nail Group
dc.contributor.institutionAirway Group
dc.contributor.institutionBioadhesive Drug Delivery Group
dc.contributor.institutionNanopharmaceutics
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.contributor.institutionToxicology
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=77955093407&partnerID=8YFLogxK
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.freeradbiomed.2010.06.013
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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