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dc.contributor.authorZeng, Bai-Yun
dc.contributor.authorIravani, Mahmoud M.
dc.contributor.authorJackson, Michael J.
dc.contributor.authorRose, Sarah
dc.contributor.authorParent, Andre
dc.contributor.authorJenner, Peter
dc.date.accessioned2013-01-11T12:29:09Z
dc.date.available2013-01-11T12:29:09Z
dc.date.issued2010-12
dc.identifier.citationZeng , B-Y , Iravani , M M , Jackson , M J , Rose , S , Parent , A & Jenner , P 2010 , ' Morphological changes in serotoninergic neurites in the striatum and globus pallidus in levodopa primed MPTP treated common marmosets with dyskinesia ' Neurobiology of Disease , vol 40 , no. 3 , pp. 599-607 . DOI: 10.1016/j.nbd.2010.08.004
dc.identifier.issn0969-9961
dc.identifier.otherPURE: 734808
dc.identifier.otherPURE UUID: 02ae9392-22a1-4a14-a014-206fda783b9f
dc.identifier.otherWOS: 000283836900010
dc.identifier.otherScopus: 77957802624
dc.identifier.urihttp://hdl.handle.net/2299/9567
dc.description.abstractHyperinnervation of the striatum by serotoninergic (5-HT) terminals occurs after destruction of the dopaminergic nigro-striatal pathway. Recent studies have suggested that non-physiological release of dopamine (DA) formed from levodopa in these serotoninergic terminals underlies abnormal involuntary movement (AIMS) induction in 6-OHDA lesioned rats. In the present study, we used tryptophan hydroxylase (TPH) immunohistochemistry to determine whether 1-methyl-4-phenyl-1,13,6-tetrahydropyridine hydrochloride (MPTP) treatment and the induction of dyskinesia by levodopa alter the morphology of 5-HT fibres in the striatum of common marmosets. The caudate-putamen of normal monkeys contained numerous fine and smooth TPH positive fibres and numerous varicose fibres, but a marked hyperinnervation of TPH positive fibres characterised by a significant increase in the number and diameter of TPH positive axon varicosities was noted in the dorsal caudate and putamen of MPTP-intoxicated monkeys but not the globus pallidus. In MPTP-intoxicated marmosets that had received chronic levodopa treatment to induce dyskinesia, a further increase in the number and enlargement of TPH positive axonal varicosities in both caudate nucleus and putamen was evident. Following LID induction, a similar pattern of increase was also observed in the external segment of the globus pallidus, but only a significant varicosity enlargement was seen in the internal pallidal segment. These results confirm that striatal 5-HT hyperinnervation follows nigro-striatal pathway loss and provide the first evidence in primates that chronic levodopa treatment and the onset of clyskinesia are associated with a marked hypertrophy of striatal 5-HT axonal varicosities. These findings support the concept that altered 5-HT function may contribute to the genesis or expression of LID.en
dc.format.extent9
dc.language.isoeng
dc.relation.ispartofNeurobiology of Disease
dc.subjectSerotonin
dc.subjectTryptophan hydroxylase
dc.subjectPrimate
dc.subjectL-DOPA
dc.subjectDyskinesia
dc.subjectDOPA-INDUCED DYSKINESIA
dc.subjectPARKINSONS-DISEASE
dc.subject1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-TREATED PRIMATES
dc.subjectSEROTONERGIC HYPERINNERVATION
dc.subjectNIGROSTRIATAL DAMAGE
dc.subjectCEREBRAL MONOAMINES
dc.subjectRECEPTOR AGONISTS
dc.subjectSUBSTANTIA-NIGRA
dc.subject5-HT1B RECEPTOR
dc.subjectBASAL GANGLIA
dc.titleMorphological changes in serotoninergic neurites in the striatum and globus pallidus in levodopa primed MPTP treated common marmosets with dyskinesiaen
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionPharmacology and Clinical Science Research
dc.contributor.institutionNeurodegenerative Diseases
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.nbd.2010.08.004
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeclosedAccess


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