dc.contributor.author | Zeng, Bai-Yun | |
dc.contributor.author | Iravani, Mahmoud M. | |
dc.contributor.author | Jackson, Michael J. | |
dc.contributor.author | Rose, Sarah | |
dc.contributor.author | Parent, Andre | |
dc.contributor.author | Jenner, Peter | |
dc.date.accessioned | 2013-01-11T12:29:09Z | |
dc.date.available | 2013-01-11T12:29:09Z | |
dc.date.issued | 2010-12 | |
dc.identifier.citation | Zeng , B-Y , Iravani , M M , Jackson , M J , Rose , S , Parent , A & Jenner , P 2010 , ' Morphological changes in serotoninergic neurites in the striatum and globus pallidus in levodopa primed MPTP treated common marmosets with dyskinesia ' , Neurobiology of Disease , vol. 40 , no. 3 , pp. 599-607 . https://doi.org/10.1016/j.nbd.2010.08.004 | |
dc.identifier.issn | 0969-9961 | |
dc.identifier.other | ORCID: /0000-0002-4905-9682/work/32997575 | |
dc.identifier.uri | http://hdl.handle.net/2299/9567 | |
dc.description.abstract | Hyperinnervation of the striatum by serotoninergic (5-HT) terminals occurs after destruction of the dopaminergic nigro-striatal pathway. Recent studies have suggested that non-physiological release of dopamine (DA) formed from levodopa in these serotoninergic terminals underlies abnormal involuntary movement (AIMS) induction in 6-OHDA lesioned rats. In the present study, we used tryptophan hydroxylase (TPH) immunohistochemistry to determine whether 1-methyl-4-phenyl-1,13,6-tetrahydropyridine hydrochloride (MPTP) treatment and the induction of dyskinesia by levodopa alter the morphology of 5-HT fibres in the striatum of common marmosets. The caudate-putamen of normal monkeys contained numerous fine and smooth TPH positive fibres and numerous varicose fibres, but a marked hyperinnervation of TPH positive fibres characterised by a significant increase in the number and diameter of TPH positive axon varicosities was noted in the dorsal caudate and putamen of MPTP-intoxicated monkeys but not the globus pallidus. In MPTP-intoxicated marmosets that had received chronic levodopa treatment to induce dyskinesia, a further increase in the number and enlargement of TPH positive axonal varicosities in both caudate nucleus and putamen was evident. Following LID induction, a similar pattern of increase was also observed in the external segment of the globus pallidus, but only a significant varicosity enlargement was seen in the internal pallidal segment. These results confirm that striatal 5-HT hyperinnervation follows nigro-striatal pathway loss and provide the first evidence in primates that chronic levodopa treatment and the onset of clyskinesia are associated with a marked hypertrophy of striatal 5-HT axonal varicosities. These findings support the concept that altered 5-HT function may contribute to the genesis or expression of LID. | en |
dc.format.extent | 9 | |
dc.format.extent | 1532134 | |
dc.language.iso | eng | |
dc.relation.ispartof | Neurobiology of Disease | |
dc.subject | Serotonin | |
dc.subject | Tryptophan hydroxylase | |
dc.subject | Primate | |
dc.subject | L-DOPA | |
dc.subject | Dyskinesia | |
dc.subject | DOPA-INDUCED DYSKINESIA | |
dc.subject | PARKINSONS-DISEASE | |
dc.subject | 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-TREATED PRIMATES | |
dc.subject | SEROTONERGIC HYPERINNERVATION | |
dc.subject | NIGROSTRIATAL DAMAGE | |
dc.subject | CEREBRAL MONOAMINES | |
dc.subject | RECEPTOR AGONISTS | |
dc.subject | SUBSTANTIA-NIGRA | |
dc.subject | 5-HT1B RECEPTOR | |
dc.subject | BASAL GANGLIA | |
dc.title | Morphological changes in serotoninergic neurites in the striatum and globus pallidus in levodopa primed MPTP treated common marmosets with dyskinesia | en |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Centre for Research in Mechanisms of Disease and Drug Discovery | |
dc.contributor.institution | Department of Clinical, Pharmaceutical and Biological Science | |
dc.contributor.institution | Basic and Clinical Science Unit | |
dc.contributor.institution | Centre for Health Services and Clinical Research | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.1016/j.nbd.2010.08.004 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |