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dc.contributor.authorMcAuley, W. J.
dc.contributor.authorOliveira, G.
dc.contributor.authorMohammed, D.
dc.contributor.authorBeezer, A. E.
dc.contributor.authorHadgraft, J.
dc.contributor.authorLane, M. E.
dc.date.accessioned2013-01-11T14:29:04Z
dc.date.available2013-01-11T14:29:04Z
dc.date.issued2010-08-30
dc.identifier.citationMcAuley , W J , Oliveira , G , Mohammed , D , Beezer , A E , Hadgraft , J & Lane , M E 2010 , ' Thermodynamic considerations of solvent/enhancer uptake into a model membrane ' , International Journal of Pharmaceutics , vol. 396 , no. 1-2 , pp. 134-139 . https://doi.org/10.1016/j.ijpharm.2010.06.040
dc.identifier.issn0378-5173
dc.identifier.otherPURE: 437592
dc.identifier.otherPURE UUID: 0f63bd52-422b-44c8-8a8f-ac9f5594894b
dc.identifier.otherWOS: 000280936000018
dc.identifier.otherScopus: 77955054579
dc.identifier.urihttp://hdl.handle.net/2299/9584
dc.description.abstractThe aim of this study was to conduct a thermodynamic analysts of the uptake of solvents into a model membrane as a precursor to skin transport studies. The investigation was designed so that the methodology may be applied to analyse data produced from measurement of the uptake of enhancers into skin. The uptake of a series of alcohols into polydimethylsiloxane (silicone) membranes in the temperature range 5-45 degrees C was examined. A thermodynamic analysis of the data was performed to provide fundamental insight into the uptake process. A simple structure activity relationship was found to exist for the uptake of alcohols with a carbon chain length greater than four, with additional methylene groups exponentially decreasing the equilibrium uptake Two separate straight lines were observed in the van't Hoff plot for the equilibrium solvent uptake above and below 16 degrees C The two separate straight lines in the van't Hoff plot suggest a change in the mechanism of solvent uptake and solvent structure in the membrane above and below 16 degrees C. This is likely to have implications for the effect of the solvents on the partitioning of drugs into the membrane and will be used to provide insight into dynamic measurements of the effect of temperature on the transport of drug molecules in the same vehicles, across the membrane. The analysis described here should provide a useful methodology for investigating the uptake of solvents into model membranes (C) 2010 Elsevier B V All rights reserveden
dc.format.extent6
dc.language.isoeng
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.subjectSolvent uptake
dc.subjectMembrane partitioning
dc.subjectTemperature effects
dc.subjectThermodynamics
dc.subjectPolydimethylsiloxane
dc.subjectCHAIN-LENGTH
dc.subjectPERCUTANEOUS-ABSORPTION
dc.subjectSILICONE MEMBRANES
dc.subjectORGANIC HOMOLOGS
dc.subjectHUMAN SKIN
dc.subjectPENETRATION
dc.subjectTEMPERATURE
dc.subjectPERMEATION
dc.subjectTRANSPORT
dc.subjectSOLVENT
dc.titleThermodynamic considerations of solvent/enhancer uptake into a model membraneen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionSkin and Nail Group
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=77955054579&partnerID=8YFLogxK
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted2010-08-30
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.ijpharm.2010.06.040
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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