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dc.contributor.authorMcAuley, William J.
dc.contributor.authorMader, Kerstin T.
dc.contributor.authorTetteh, John
dc.contributor.authorLane, Majella E.
dc.contributor.authorHadgraft, Jonathan
dc.date.accessioned2013-01-11T14:29:08Z
dc.date.available2013-01-11T14:29:08Z
dc.date.issued2009-11-05
dc.identifier.citationMcAuley , W J , Mader , K T , Tetteh , J , Lane , M E & Hadgraft , J 2009 , ' Simultaneous monitoring of drug and solvent diffusion across a model membrane using ATR-FTIR spectroscopy ' , European Journal of Pharmaceutical Sciences , vol. 38 , no. 4 , pp. 378-383 . https://doi.org/10.1016/j.ejps.2009.09.002
dc.identifier.issn0928-0987
dc.identifier.otherPURE: 437802
dc.identifier.otherPURE UUID: d2bd232d-78b9-4687-a623-7f55bf53a8c0
dc.identifier.otherWOS: 000271698900013
dc.identifier.otherScopus: 70349822937
dc.identifier.urihttp://hdl.handle.net/2299/9586
dc.description.abstractAttenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy has been used to simultaneously follow the diffusion of model drugs and solvent across polydimethylsiloxane (silicone) membrane. Three model drugs, cyanophenol (CNP), methyl nicotinate (MN) and butyl paraben (BP) were selected to cover a range of lipophilicities. Isostearyl isostearate (ISIS) was chosen as the solvent because its large molecular weight should facilitate observation of whether the drug molecules are able to diffuse through the membrane independently of the solvent. The diffusion of the three drugs and the solvent was successfully described by a Fickian model. The effects of parameters such as the absorption wavelength used to follow diffusion on the calculated diffusion coefficient were investigated. Absorption wavelength which affects the depth of penetration of the infrared radiation into the membrane did not significantly affect the calculated diffusion coefficient over the wavelength range tested. Each of the model drugs was observed to diffuse independently of the solvent across the membrane. The diffusion of a CNP-ISIS hydrogen bonded complex across the membrane was also monitored. The relative diffusion rates of the solute and solvent across the membrane can largely be accounted for by the molecular size of the permeant. (C) 2009 Elsevier B.V. All rights reserved.en
dc.format.extent6
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Pharmaceutical Sciences
dc.subjectDiffusion
dc.subjectSolvation
dc.subjectPolydimethylsiloxane
dc.subjectPenetration enhancement
dc.subjectATR-FTIR spectroscopy
dc.subjectINTERNAL-REFLECTION SPECTROSCOPY
dc.subjectIN-VITRO
dc.subjectTRANSDERMAL DELIVERY
dc.subjectSYNTHETIC MEMBRANES
dc.subjectSOLUTE INTERACTIONS
dc.subjectSILICONE MEMBRANES
dc.subjectPERMEABILITY DATA
dc.subjectPROPYLENE-GLYCOL
dc.subjectSKIN PERMEATION
dc.subjectBENZOIC-ACID
dc.titleSimultaneous monitoring of drug and solvent diffusion across a model membrane using ATR-FTIR spectroscopyen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionSkin and Nail Group
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted2009-11-05
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.ejps.2009.09.002
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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