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dc.contributor.authorMurnane, Darragh
dc.contributor.authorMartin, Gary P.
dc.contributor.authorMarriott, Christopher
dc.date.accessioned2013-01-11T14:59:03Z
dc.date.available2013-01-11T14:59:03Z
dc.date.issued2008-10
dc.identifier.citationMurnane , D , Martin , G P & Marriott , C 2008 , ' Investigations into the formulation of metered dose inhalers of salmeterol xinafoate and fluticasone propionate microcrystals ' , Pharmaceutical Research , vol. 25 , no. 10 , pp. 2283-2291 . https://doi.org/10.1007/s11095-008-9622-3
dc.identifier.issn0724-8741
dc.identifier.otherPURE: 397780
dc.identifier.otherPURE UUID: 79909512-da48-421c-828a-3571dcdcc390
dc.identifier.otherWOS: 000259187800009
dc.identifier.otherScopus: 51649117524
dc.identifier.urihttp://hdl.handle.net/2299/9588
dc.description.abstractPurpose. To investigate the aerosolization and behaviour of microparticles of salmeterol xinafoate (SX) and fluticasone propionate (FP) suspended in hydrofluoroalkane (HFA) propellant. Methods. Microcrystals of SX and FP were produced from poly(ethylene glycol) by antisolvent crystallization. The suspension behaviour and aerosolization of the microcrystals when formulated as metered dose inhalers (MDIs) in HFA 134a propellant was compared with that of microparticles produced by micronization (mSX and mFP) using a glass twin stage impinger and by laser light diffraction using a pressurized cell. Results. FP microparticles underwent non-reversible aggregation in suspension as seen by a doubling in the volume median diameter compared to the raw material. The degree of aggregation of SX particles in suspension was found to decrease as the particle size of the original particles increased. However, because the SX aggregate size was lowest for the particles with the smallest initial size (mSX), the highest fine particle fraction (FPF) of SX was obtained from a suspension of mSX. The FPFs following aerosolization of FP suspensions were similar although the FPF was lowest for particles with the largest original size. Conclusions. The size of the aggregates in the HFA suspensions was found to correlate directly with the FPFs determined by impaction.en
dc.format.extent9
dc.language.isoeng
dc.relation.ispartofPharmaceutical Research
dc.subjectaggregation
dc.subjectfluticasone propionate
dc.subjectmetered dose inhaler
dc.subjectmicrocrystals
dc.subjectsalmeterol xinafoate
dc.subjectsuspension
dc.subjectAERODYNAMIC PARTICLE-SIZE
dc.subjectATOMIC-FORCE MICROSCOPY
dc.subjectINHALATION AEROSOLS
dc.subjectSURFACE ENERGETICS
dc.subjectPERFORMANCE
dc.subjectAGGREGATION
dc.subjectPRESSURE
dc.subjectBEHAVIOR
dc.subjectSYSTEM
dc.titleInvestigations into the formulation of metered dose inhalers of salmeterol xinafoate and fluticasone propionate microcrystalsen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionAirway Group
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.description.statusPeer reviewed
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1007/s11095-008-9622-3
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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