Pharmacokinetic evaluation of intranasally administered vinyl coated lorazepam microparticles in rabbits
Author
Zhao, Yanjun
Khengar, Raj
Traynor, M.J.
Barata, Pedro
Brown, Marc
Jones, Stuart
Attention
2299/9602
Abstract
The intranasal (IN) administration of lorazepam is desirable in order to maximize speed of onset and minimise carry-over sedation; however, this benzodiazepine is prone to chemical hydrolysis and poor airway retention, and thus, innovative epithelial presentation is required. The aim of this study was to understand how the in situ self-assembly of a mucoretentive delivery system, formed by the dissolution of vinyl polymer-coated microparticles in the nasal mucosa, would influence lorazepam pharmacokinetics (PK).