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Epidermal growth factor upregulates motility of Mat-LyLu rat prostate cancer cells partially via voltage-gated Na+ channel activity.

dc.contributor.authorDing, Yanning
dc.contributor.authorBrackenbury, William J.
dc.contributor.authorOnganer, Pinar U.
dc.contributor.authorMontano, Ximena
dc.contributor.authorPorter, Louise M.
dc.contributor.authorBates, Lucy F.
dc.contributor.authorDjamgoz, Mustafa B.A.
dc.date.accessioned2013-01-21T14:58:51Z
dc.date.available2013-01-21T14:58:51Z
dc.date.issued2008-04
dc.identifier.citationDing , Y , Brackenbury , W J , Onganer , P U , Montano , X , Porter , L M , Bates , L F & Djamgoz , M B A 2008 , ' Epidermal growth factor upregulates motility of Mat-LyLu rat prostate cancer cells partially via voltage-gated Na+ channel activity. ' , Journal of Cellular Physiology , vol. 215 , no. 1 , pp. 77-81 . https://doi.org/10.1002/jcp.21289
dc.identifier.issn1097-4652
dc.identifier.otherPURE: 952152
dc.identifier.otherPURE UUID: 52a8a040-04d2-434f-8451-2c1179801cff
dc.identifier.otherScopus: 39149115129
dc.identifier.urihttp://hdl.handle.net/2299/9735
dc.description.abstractThe main aim of this investigation was to determine whether a functional relationship existed between epidermal growth factor (EGF) and voltage-gated sodium channel (VGSC) upregulation, both associated with strongly metastatic prostate cancer cells. Incubation with EGF for 24 h more than doubled VGSC current density. Similar treatment with EGF significantly and dose-dependently enhanced the cells' migration through Transwell filters. Both the patch clamp recordings and the migration assay suggested that endogenous EGF played a similar role. Importantly, co-application of EGF and tetrodotoxin, a highly selective VGSC blocker, abolished 65% of the potentiating effect of EGF. It is suggested that a significant portion of the EGF-induced enhancement of migration occurred via VGSC activityen
dc.format.extent5
dc.language.isoeng
dc.relation.ispartofJournal of Cellular Physiology
dc.titleEpidermal growth factor upregulates motility of Mat-LyLu rat prostate cancer cells partially via voltage-gated Na+ channel activity.en
dc.contributor.institutionParamedic Science
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionAllied Health Professions
dc.contributor.institutionDepartment of Allied Health Professions and Midwifery
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=39149115129&partnerID=8YFLogxK
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1002/jcp.21289
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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