dc.contributor.author | Ding, Yanning | |
dc.contributor.author | Brackenbury, William J. | |
dc.contributor.author | Onganer, Pinar U. | |
dc.contributor.author | Montano, Ximena | |
dc.contributor.author | Porter, Louise M. | |
dc.contributor.author | Bates, Lucy F. | |
dc.contributor.author | Djamgoz, Mustafa B.A. | |
dc.date.accessioned | 2013-01-21T14:58:51Z | |
dc.date.available | 2013-01-21T14:58:51Z | |
dc.date.issued | 2008-04 | |
dc.identifier.citation | Ding , Y , Brackenbury , W J , Onganer , P U , Montano , X , Porter , L M , Bates , L F & Djamgoz , M B A 2008 , ' Epidermal growth factor upregulates motility of Mat-LyLu rat prostate cancer cells partially via voltage-gated Na+ channel activity. ' , Journal of Cellular Physiology , vol. 215 , no. 1 , pp. 77-81 . https://doi.org/10.1002/jcp.21289 | |
dc.identifier.issn | 1097-4652 | |
dc.identifier.uri | http://hdl.handle.net/2299/9735 | |
dc.description.abstract | The main aim of this investigation was to determine whether a functional relationship existed between epidermal growth factor (EGF) and voltage-gated sodium channel (VGSC) upregulation, both associated with strongly metastatic prostate cancer cells. Incubation with EGF for 24 h more than doubled VGSC current density. Similar treatment with EGF significantly and dose-dependently enhanced the cells' migration through Transwell filters. Both the patch clamp recordings and the migration assay suggested that endogenous EGF played a similar role. Importantly, co-application of EGF and tetrodotoxin, a highly selective VGSC blocker, abolished 65% of the potentiating effect of EGF. It is suggested that a significant portion of the EGF-induced enhancement of migration occurred via VGSC activity | en |
dc.format.extent | 5 | |
dc.format.extent | 133866 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Cellular Physiology | |
dc.title | Epidermal growth factor upregulates motility of Mat-LyLu rat prostate cancer cells partially via voltage-gated Na+ channel activity. | en |
dc.contributor.institution | Paramedic Science | |
dc.contributor.institution | Health & Human Sciences Research Institute | |
dc.contributor.institution | Allied Health Professions | |
dc.contributor.institution | Department of Allied Health Professions and Midwifery | |
dc.description.status | Peer reviewed | |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=39149115129&partnerID=8YFLogxK | |
rioxxterms.versionofrecord | 10.1002/jcp.21289 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |