Show simple item record

dc.contributor.authorTrivedi, Daksha
dc.contributor.authorKirby, Michael
dc.contributor.authorNorman, Felicity
dc.contributor.authorPrzybytniak, Izabela
dc.contributor.authorAli, Shehzad
dc.contributor.authorWellsted, D.
dc.date.accessioned2013-01-22T14:58:44Z
dc.date.available2013-01-22T14:58:44Z
dc.date.issued2011-12-01
dc.identifier.citationTrivedi , D , Kirby , M , Norman , F , Przybytniak , I , Ali , S & Wellsted , D 2011 , ' Can simvastatin improve erectile function and health-related quality of life in men aged over 40 years with erectile dysfunction? Rationale and design of the Erectile Dysfunction and Statins (EDS) Trial [ISRCTN66772971] ' , British Journal of Urology , vol. 108 , no. 11 , pp. 1850-1854 . https://doi.org/10.1111/j.1464-410X.2011.10122.x
dc.identifier.otherPURE: 382291
dc.identifier.otherPURE UUID: 1c23f82c-e49a-4be9-98c3-36a9422bfe79
dc.identifier.otherPubMed: 21371242
dc.identifier.otherScopus: 81255158345
dc.identifier.urihttp://hdl.handle.net/2299/9754
dc.description© 2011 UNIVERSITY OF HERTFORDSHIRE. BJU INTERNATIONAL © 2011 BJU INTERNATIONAL.
dc.description.abstractOBJECTIVE To describe the rationale and design of the Erectile Dysfunction and Statins (EDS) Trial which aims to evaluate the effectiveness of simvastatin on erectile function and health-related quality of life in men aged ≥40 years with erectile dysfunction. PATIENTS AND METHODS The study is a randomized, double-blind, placebo-controlled trial to test the hypotheses that statins improve endothelial function and reduce cholesterol and may improve erectile function in men with untreated erectile dysfunction (ED). Study subjects are men ≥40 years who are not receiving lipid-lowering or anti-hypertensive medication and have no other cardiovascular disease (CVD) risk factors. Eligible men with untreated ED are randomized to double-blind treatment with 40 mg simvastatin or placebo once daily for 6 months. Data are collected at baseline, mid-trial and at the final follow-up visit at 30 weeks. The main outcome is erectile function measured by the five-item version of the International Index of Erectile Function. Secondary outcomes include sexual-health-related quality of life and endothelial function. RESULTS Ten general practices have been recruited in the east of England. We have randomized 173 men for a power of 90% to assess the main outcome. To date there have been no serious unexpected adverse events. Study findings will be available in September 2011. CONCLUSIONS If simvastatin improves erectile function it would provide an inexpensive treatment for ED suitable for most men, and reduce the risk of future CVD.en
dc.format.extent5
dc.language.isoeng
dc.relation.ispartofBritish Journal of Urology
dc.subjecterectile dysfunction
dc.subjectsimvastatin
dc.subjectcardiovascular risk
dc.subjecthealth related quality of life
dc.titleCan simvastatin improve erectile function and health-related quality of life in men aged over 40 years with erectile dysfunction? : Rationale and design of the Erectile Dysfunction and Statins (EDS) Trial [ISRCTN66772971]en
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionDepartment of Adult Nursing and Primary Care
dc.contributor.institutionEvidence Based Practice
dc.contributor.institutionEDS Trial
dc.contributor.institutionCentre for Research in Public Health and Community Care
dc.contributor.institutionPatient Experience and Public Involvement
dc.contributor.institutionNursing, Midwifery and Social Work
dc.contributor.institutionCentre for Postgraduate Medicine
dc.contributor.institutionHealth and Human Sciences Central
dc.contributor.institutionApplied and Practice-based Research
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Psychology
dc.contributor.institutionPsychology
dc.contributor.institutionCentre for Lifespan and Chronic Illness Research
dc.contributor.institutionHealth and Clinical Psychology group
dc.contributor.institutionHealth Services and Medicine
dc.contributor.institutionStatistics and Methodology Research group
dc.contributor.institutionHealth Services Research group
dc.contributor.institutionOlder People's Health and Complex Conditions
dc.contributor.institutionWeight and Obesity Research Group
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=81255158345&partnerID=8YFLogxK
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1111/j.1464-410X.2011.10122.x
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record