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dc.contributor.authorSpalding, E.M.
dc.contributor.authorChandra, S.M.
dc.contributor.authorDavenport, A.
dc.contributor.authorFarrington, Ken
dc.date.accessioned2013-02-05T10:00:06Z
dc.date.available2013-02-05T10:00:06Z
dc.date.issued2008
dc.identifier.citationSpalding , E M , Chandra , S M , Davenport , A & Farrington , K 2008 , ' Kt/V underestimates the hemodialysis dose in women and small men ' , Kidney international , vol. 74 , no. 3 , pp. 348-355 . https://doi.org/10.1038/ki.2008.185
dc.identifier.issn0085-2538
dc.identifier.otherPURE: 130702
dc.identifier.otherPURE UUID: 39f20af4-4599-4c7d-9f64-fcf12030cab7
dc.identifier.otherdspace: 2299/5693
dc.identifier.otherScopus: 47349102769
dc.identifier.urihttp://hdl.handle.net/2299/9880
dc.descriptionOriginal article can be found at : http://www.nature.com/ Copyright Nature Publishing Group [Full text of this article is not available in the UHRA]
dc.description.abstractCurrent guidelines suggest a minimum Kt/V of 1.2 for three weekly hemodialysis sessions; however, using V as a normalizing factor has been questioned. Parameters such as weight^0.67 (W0.67) and body surface area (BSA) that reflect the metabolic rate may be preferable. To determine this, we studied 328 hemodialysis patients (221 male) with a target Kt/V of 1.2. Using this relationship and the individual's Watson Volume, we calculated the Kt, Kt/BSA, and Kt/W^0.67 equivalent to the target and measured the effects of body size and gender on these parameters for each patient. The target corresponded to a range of equivalent Kt/BSA and Kt/W^0.67 each significantly higher in males than females and in larger than smaller males. V/BSA and V/W^0.67, the conversion factors of Kt/V to Kt/BSA and Kt/W^0.67 respectively, were significantly greater in males than females and heavier than lighter men. Our study shows that if Kt/BSA and Kt/W^0.67 reflect the true required dose, prescribing a target Kt/V of 1.2 would underestimate this in females and in small males. Further work is required to develop clinical outcome-based adequacy targets.en
dc.language.isoeng
dc.relation.ispartofKidney international
dc.subjecthemodialysis
dc.subjectadequacy
dc.subjectKt/V
dc.subjectmetabolic size
dc.subjectbody surface area
dc.subjecttotal body water
dc.titleKt/V underestimates the hemodialysis dose in women and small menen
dc.contributor.institutionCentre for Postgraduate Medicine
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionPostgraduate Medicine
dc.contributor.institutionHealth Services and Medicine
dc.description.statusPeer reviewed
dcterms.dateAccepted2008
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1038/ki.2008.185
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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