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dc.contributor.authorShiu, Winnie K. P.
dc.contributor.authorRahman, M. Mukhlesur
dc.contributor.authorCurry, Jonathan
dc.contributor.authorStapleton, Paul
dc.contributor.authorZloh, Mire
dc.contributor.authorMalkinson, John P.
dc.contributor.authorGibbons, Simon
dc.identifier.citationShiu , W K P , Rahman , M M , Curry , J , Stapleton , P , Zloh , M , Malkinson , J P & Gibbons , S 2012 , ' Antibacterial acylphloroglucinols from Hypericum olympicum ' , Journal of Natural Products , vol. 75 , no. 3 , pp. 336-43 .
dc.identifier.otherPURE: 1457192
dc.identifier.otherPURE UUID: 288bf61b-f333-4016-ba3f-34fc23d14c21
dc.identifier.otherPubMed: 21899267
dc.identifier.otherScopus: 84859050820
dc.description.abstractNew antibacterial acylphloroglucinols (1-5) were isolated and characterized from the aerial parts of the plant Hypericum olympicum L. cf. uniflorum. The structures of these compounds were confirmed by extensive 1D- and 2D-NMR experiments to be 4,6-dihydroxy-2-O-(3″,7″-dimethyl-2″,6″-octadienyl)-1-(2'-methylbutanoyl)benzene (1), 4,6-dihydroxy-2-O-(7″-hydroxy-3″,7″-dimethyl-2″,5″-octadienyl)-1-(2'-methylbutanoyl)benzene (2), 4,6-dihydroxy-2-O-(6″-hydroxy-3″,7″-dimethyl-2″,7″-octadienyl)-1-(2'-methylbutanoyl)benzene (3), 4,6-dihydroxy-2-O-(6″-hydroperoxy-3″,7″-dimethyl-2″,7″-octadienyl)-1-(2'-methylbutanoyl)benzene (4), and 4,6-dihydroxy-2-O-(6″,7″-epoxy-3″,7″-dimethyloct-2″-enyl)-1-(2'-methylbutanoyl)benzene (5). These new natural products have been given the trivial names olympicins A-E (1-5). All compounds were evaluated against a panel of methicillin-resistant Staph. aureus and multidrug-resistant strains of Staph. aureus. Compound 1 exhibited minimum inhibitory concentrations (MICs) of 0.5-1 mg/L against the tested Staph. aureus strains. Compounds 2 to 5 were also shown to be active, with MICs ranging from 64 to 128 mg/L. Compound 1 was synthesized using a simple four-step method that can be readily utilized to give a number of structural analogues of 1.en
dc.relation.ispartofJournal of Natural Products
dc.titleAntibacterial acylphloroglucinols from Hypericum olympicumen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionMedicinal and Analytical Chemistry
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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