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dc.contributor.authorWood, D.G.
dc.contributor.authorBrown, Marc
dc.contributor.authorJones, S.A.
dc.date.accessioned2013-02-13T17:00:04Z
dc.date.available2013-02-13T17:00:04Z
dc.date.issued2012-08-01
dc.identifier.citationWood , D G , Brown , M & Jones , S A 2012 , ' Understanding heat facilitated drug transport across human epidermis ' , European Journal of Pharmaceutics and Biopharmaceutics , vol. 81 , no. 3 , pp. 642-649 . https://doi.org/10.1016/j.ejpb.2012.03.019
dc.identifier.issn0939-6411
dc.identifier.otherPURE: 988189
dc.identifier.otherPURE UUID: cb107528-4adc-49ec-8a21-485734da9925
dc.identifier.otherScopus: 84863774301
dc.identifier.urihttp://hdl.handle.net/2299/9999
dc.descriptionCopyright 2012 Elsevier B.V., All rights reserved.
dc.description.abstractThe application of moderate heat is a safe and effective means to increase drug transport across human skin. However, the cascade of events that follows the exposure of a topical skin formulation to a heating source is not well understood. The aim of this study was to elucidate how three potential rate limiting stages in the drug transport process; formulation release, drug partitioning and epidermal diffusion, responded to changes in local temperature using the model drug lidocaine. Release from the formulation measured using regenerated cellulose membrane was shown to be driven by drug diffusion in the vehicle; it responded linearly when the local temperature was changed (21.6 μg/cm2/h for every 1 °C rise) and displayed no measurable partitioning of lidocaine into RCM. Once the drug was within the human epidermis, the structural changes of the barrier controlled its transport. The apparent lidocaine diffusion coefficient through silicone membrane increased from 6.52 to 8.43 × 10−4 over the 32–45 °C temperature range, but it increased from 7.74 × 10−5 cm2 h−1 to 4.8 × 10−4 cm2 h−1 in the human epidermis. In the absence of large increases in drug partitioning, fluidisation of the lipids in the upper layers of the epidermis at 37–45 °C was shown to facilitate lidocaine diffusion which for human skin transport was the rate limiting process.en
dc.format.extent8
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Pharmaceutics and Biopharmaceutics
dc.titleUnderstanding heat facilitated drug transport across human epidermisen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionSkin and Nail Group
dc.contributor.institutionAirway Group
dc.contributor.institutionBioadhesive Drug Delivery Group
dc.contributor.institutionNanopharmaceutics
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.contributor.institutionToxicology
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84863774301&partnerID=8YFLogxK
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.ejpb.2012.03.019
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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