Harnessing viral internal proteins to combat flu and beyond
This mini-review examines the strategy of combining viral protein sequence conservation with drug-binding potential to identify novel antiviral targets, focusing on internal proteins of influenza A and other RNA viruses. The importance of combating viral genetic variability and reducing the likelihood of resistance development is emphasised in the context of sequence redundancy in viral datasets. It covers recent structural and functional updates, as well as drug targeting efforts for three internal influenza A viral proteins: Basic Polymerase 2, Nuclear Export Protein, and Nucleoprotein. The review discusses new insights into protein interactions, potential inhibitors, and recent drug discovery efforts. Similar approaches beyond influenza including Hepatitis E, SARS-CoV-2, Dengue, and the HIV-1 virus are also covered briefly.
Item Type | Article |
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Additional information | © 2025 The Authors. Published by Elsevier Inc. This is an open access article distributed under the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/ |
Keywords | conservation, binding site, sequence redundancy, virtual screening, computational drug discovery, biochemistry, genetics and molecular biology (miscellaneous), virology, drug discovery |
Date Deposited | 15 May 2025 15:50 |
Last Modified | 31 May 2025 00:47 |
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