Using real-valued metaclassifiers to integrate binding site predictions

Sun, Yi, Robinson, M., Adams, Roderick, Kaye, Paul H., Rust, A.G. and Davey, N. (2005) Using real-valued metaclassifiers to integrate binding site predictions. In: In: Procs of IJCNN 2005, Int Joint Conference on Neural networks :. Institute of Electrical and Electronics Engineers (IEEE), pp. 481-486.
Copy

Currently the best algorithms for transcription factor binding site prediction are severely limited in accuracy. There is good reason to believe that predictions from these different classes of algorithms could be used in conjunction to improve the quality of predictions. In this paper, we apply single layer networks, rules sets and support vector machines on predictions from 12 key real valued algorithms. Furthermore, we use a ‘window’ of consecutive results in the input vector in order to contextualise the neighbouring results. We improve the classification result with the aid of under- and over- sampling techniques. We find that support vector machines outperform each of the original individual algorithms and the other classifiers employed in this work. In particular they have a better tradeoff between recall and precision.


picture_as_pdf
900863.pdf
subject
Submitted Version

View Download

Atom BibTeX OpenURL ContextObject in Span OpenURL ContextObject Dublin Core MPEG-21 DIDL Data Cite XML EndNote HTML Citation METS MODS RIOXX2 XML Reference Manager Refer ASCII Citation
Export

Downloads