Developmental evolution of dendritic morphology in a multi-compartmental neuron model

Rust, A.G. and Adams, R.G. (1999) Developmental evolution of dendritic morphology in a multi-compartmental neuron model. In: UNSPECIFIED.

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Through the use of a multi-compartmental neuron simulation, Mainen and Sejnowski demonstrated that spike generation in neurons is a function of their dendritic structure [l]. In this paper we investigate the determination of dendritic morphology given a desired set of spike traces. A genetic algorithm is used to identify optimal parameters for a developmental model which simulates the growth of 3-dimensional dendrites. For two ’classes of ’neurons with different spiking behaviour, the developmental evolutionary process discovers ranges of viable dendritic morphologies which satisfactorally match the desired spike traces.

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Date Deposited	15 May 2025 16:25
Last Modified	04 Feb 2026 00:15