NK1 antagonists based on seven membered lactam scaffolds
Elliott, J. M., Carlson, E. J., Chcchi, G. G., Dirat, O., Dominguez, M., Gerhard, U., Jelley, R., Jones, A. B., Kurtz, M. M., Tsao, K. I. and Wheeldon, A.
(2006)
NK1 antagonists based on seven membered lactam scaffolds.
Bioorganic and Medicinal Chemistry Letters (11).
pp. 2929-2932.
ISSN 0960-894X
A new class of high affinity hNK(1)R antagonists based on seven-membered ring cores has been identified. This series, with relatively simple, compact structures, includes compounds with high affinity, good selectivity, and promising in vivo properties. (c) 2006 Elsevier Ltd. All rights reserved.
| Item Type | Article |
|---|---|
| Date Deposited | 29 May 2025 09:03 |
| Last Modified | 29 May 2025 09:03 |