Statistical evaluation of influence of xanthan gum and guar gum blends on dipyridamole release from floating matrix tablets
Patel, Viral F. and Patel, Natavarlal M.
(2007)
Statistical evaluation of influence of xanthan gum and guar gum blends on dipyridamole release from floating matrix tablets.
Drug Development and Industrial Pharmacy (3).
pp. 327-34.
ISSN 0363-9045
The present investigation explored the use of xanthan gum and guar gum for development of floating drug delivery system of dipyridamole using factorial design approach. The content of polymer blends (X(1)) and ratio of xanthan gum to guar gum (X(2)) were selected as independent variables. The diffusion exponent (n), release rate constant (k), percentage drug release at 1 hr (Q(1)) and 6 hr (Q(6)) were selected as dependent variables. Tablets of all batches had desired buoyancy characteristics. Multiple regression analysis with two way ANOVA revealed that both the factors had statistically significant influence on the response studied (p
Item Type | Article |
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Keywords | Analysis of Variance; Diffusion; Dipyridamole; Drug Carriers; Drug Delivery Systems; Factor Analysis, Statistical; Galactans; Mannans; Plant Gums; Polysaccharides, Bacterial; Tablets; Vasodilator Agents |
Date Deposited | 29 May 2025 09:04 |
Last Modified | 29 May 2025 09:04 |