Dynein-dynactin complex subunits are differentially localized in brain and spinal cord, with selective involvement in pathological features of neurodegenerative disease
Ateh, D. D., Hussain, I. K., Mustafa, A. H., Price, K. M., Gulati, R., Nickols, C. D., Bird, M. M., Greensmith, L., Hafezparast, M., Fisher, E. M. C., Baker, C. S. and Martin, J. E.
(2008)
Dynein-dynactin complex subunits are differentially localized in brain and spinal cord, with selective involvement in pathological features of neurodegenerative disease.
Neuropathology and Applied Neurobiology (1).
pp. 88-94.
ISSN 0305-1846
The dynein-dynactin complex, mostly recognized for axonal retrograde transport in neurones, has an ever growing list of essential subcellular functions. Here, the distribution of complex subunits in human central nervous system (CNS) has been assessed using immunohistochemistry in order to test the hypothesis that this may be altered in neurodegenerative disease.
| Item Type | Article |
|---|---|
| Keywords | Spinal Cord; Microtubule-Associated Proteins; Neurons; Inclusion Bodies; Humans; Brain; Neurodegenerative Diseases; Neurofibrillary Tangles; Immunohistochemistry; Dyneins |
| Subjects |
Biochemistry, Genetics and Molecular Biology(all) > General Biochemistry,Genetics and Molecular Biology Neuroscience(all) > General Neuroscience |
| Date Deposited | 29 May 2025 09:05 |
| Last Modified | 29 May 2025 09:05 |