CCR2B receptor antagonists : Conversion of a weak HTS hit to a potent lead compound
Forbes, Ian T., Cooper, David G., Dodds, Emma K., Hickey, Deirdre M. B., Ife, Robert J., Meeson, Malcolm, Stockley, Martin, Berkhout, Theo, Gohil, Jayneeta, Groot, Pieter H. E. and Moores, Kitty E.
(2000)
CCR2B receptor antagonists : Conversion of a weak HTS hit to a potent lead compound.
Bioorganic and Medicinal Chemistry Letters (16).
pp. 1803-1806.
ISSN 0960-894X
A weak HTS hit at the CCR2B receptor has been converted into a potent antagonist by array SAR studies. Selectivity over the closely related CCR5 receptor is also achieved. (C) 2000 Elsevier Science Ltd. All rights reserved.
| Item Type | Article |
|---|---|
| Subjects |
Biochemistry, Genetics and Molecular Biology(all) > Biochemistry Biochemistry, Genetics and Molecular Biology(all) > Molecular Biology Chemistry(all) > Organic Chemistry Pharmacology, Toxicology and Pharmaceutics(all) > Drug Discovery Pharmacology, Toxicology and Pharmaceutics(all) > Pharmaceutical Science |
| Date Deposited | 29 May 2025 09:06 |
| Last Modified | 29 May 2025 09:06 |