Influence of alcohol on the release of tramadol from 24-h controlled-release formulations during in vitro dissolution experiments
Traynor, M.J., Brown, Marc, Pannala, A., Beck, P. and Martin, G. P.
(2008)
Influence of alcohol on the release of tramadol from 24-h controlled-release formulations during in vitro dissolution experiments.
Drug Development and Industrial Pharmacy, 34 (8).
pp. 885-889.
ISSN 0363-9045
Recent warnings by regulatory bodies and a product recall by the FDA have generated much interest in the area of dose dumping from controlled-release opioid analgesic formulations when coingested with alcohol. It was the aim of this study to address this issue and in doing so, gain understanding on how alcohol-induced effects may be avoided. In this study, tramadol release from Ultram (R) ER tablets and T-long (R) capsules was significantly increased in the presence of ethanol. Conversely, a decrease in the rate of tramadol release was seen from Tridural (TM) extended-release tablets in the presence of alcohol.
Item Type | Article |
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Additional information | Original article can be found at: http://www.informaworld.com/smpp/1903179435-18973042/title~content=t713597245 Copyright Informa Healthcare |
Keywords | tramadol, controlled release, alcohol, in vitro, postoperative pain, matrices |
Date Deposited | 15 May 2025 12:05 |
Last Modified | 30 May 2025 23:44 |
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