Opto-thermal measurement of barrier cream residence time on skin in-vivo

Guo, X. X., Ciortea, L. I., Chilcott, Robert, Imhof, R. E. and Xiao, P. (2001) Opto-thermal measurement of barrier cream residence time on skin in-vivo. Analytical Sciences. S346-S348. ISSN 0910-6340
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We report the non-invasive opto-thermal measurement of the residence time of a barrier cream on in-vivo skin. These measurements revealed an approximately exponential decrease of cream layer thickness with a 1/e disappearance time of similar to 60 minutes. Measurements on a cream layer on a polymer substrate under otherwise similar conditions confirmed that penetration into the stratum corneum, rather than abrasion or evaporative loss, was the main cause of the observed disappearance.

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