Optimisation of antihypertensive treatment by crossover rotation of four major classes

Dickerson, Claire, Hingorani, A.D., Ashby, M.J., Palmer, C.R. and Brown, M.J. (1999) Optimisation of antihypertensive treatment by crossover rotation of four major classes. Lancet (9169). pp. 2008-2013. ISSN 0140-6736
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Most comparisons of antihypertensive drugs aee undertaken in parallel groups. We undertook a crossover rotation of the four main classes of antihypertensive drugs, in untreated young hypertensive patients, to assess the response rate with monotherapy achieved by a systematic rotation.

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