Association of the Gsα Gene With Essential Hypertension and Response to ß-Blockade

Jia, H., Hingorani, A.D., Sharma, P., Hopper, R., Dickerson, Claire, Trutwein, D., Lloyd, D.D. and Brown, M.J. (1999) Association of the Gsα Gene With Essential Hypertension and Response to ß-Blockade. Hypertension (1). pp. 8-14. ISSN 0194-911X
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We examined whether the GNAS1 locus, encoding the Gs protein α-subunit (Gsα), is implicated in the genetic causes of essential hypertension. A common silent polymorphism (ATTATC, Ile131) was identified in exon 5 of the Gsα gene by single-strand conformation polymorphism analysis and DNA sequencing. This polymorphism consists of the presence (+) or absence (-) of a restriction site for FokI. Only 1 other rare allele was found in the coding region; the high GC content of the 5' noncoding sequence prevented mutation scanning of the promoter region of the gene. There was a significant difference in frequency of the FokI alleles between 268 white hypertensives (FokI+:FokI-, 51%:49%) and a matched group of 231 control subjects (FokI+:FokI-, 58%:42%) (P=0.02). Multiple regression analysis showed that the FokI genotype was independently related to the level of untreated systolic blood pressure in 294 well-characterized white hypertensives (P=0.01) but not in normotensives. The influence of the FokI allele on blood pressure (BP) response to ß-blockade was examined in 114 of the patients randomly assigned to this class of drug. Significant differences in frequency of the FokI allele were observed in the good responders (FokI+:FokI-, 62.5%:37.5%, n=36) versus the poor responders (FokI+:FokI-, 41.7%:58.3%, n=30) after ß-blocker therapy (P=0.02). In a multiple regression analysis, the Gsα genotype was the only independent predictor of BP response. These results suggest that the GNAS1 locus might carry a functional variant that influences BP variation and response to ß-blockade in essential hypertension.

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