Advances in oral transmucosal drug delivery
The successful delivery of drugs across the oral mucosa represents a continuing challenge, as well as a great opportunity. Oral transmucosal delivery, especially buccal and sublingual delivery, has progressed far beyond the use of traditional dosage forms with novel approaches emerging continuously. This review highlights the physiological challenges as well as the advances and opportunities for buccal/sublingual drug delivery. Particular attention is given to new approaches which can extend dosage form retention time or can be engineered to deliver complex molecules such as proteins and peptides. The review will also discuss the physiology and local environment of the oral cavity in vivo and how this relates to the performance of transmucosal delivery systems.
Item Type | Article |
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Additional information | Original article can be found at : http://sciencedirect.com/ Copyright Elsevier |
Keywords | transmucosal, permeation pathways, buccal absorption, mucoadhesive, dosage forms, porcine buccal mucosa, in-vitro evaluation, carrier-mediated transport, membrane-coating granules, cell-culture model, mucoadhesive polymers, transbuccal delivery, gastrointestinal-tract |
Date Deposited | 15 May 2025 12:11 |
Last Modified | 06 Jun 2025 00:02 |
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