Targeting glycolysis : a fragment based approach towards bifunctional inhibitors of hLDH-5

Moorhouse, Adam D., Spiteri, Christian, Sharma, Pallavi, Zloh, Mire and Moses, John E. (2011) Targeting glycolysis : a fragment based approach towards bifunctional inhibitors of hLDH-5. Chemical Communications (1). pp. 230-2. ISSN 1364-548X
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hLDH-5 has emerged as a promising target for anti-glycolytic cancer chemotherapy. Here we report a first generation of bifunctional inhibitors, which show promising activity against hLDH-5.

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