Adhesion G protein-coupled receptors

Formstone, Caroline, Langenhan, Tobias, Anderson, Garret, Araç, Demet, Aust, Gabriela, Avila-Zozaya, Monserrat, Bagger, Sofie Morsing, Barth, Patrick, Berndt, Sandra, Blacklow, Stephen C., Blanco-Redondo, Beatriz, Boucard, Antony A., Bridges, James, Brodmerkel, Lara-Sophie, Caron, Kathleen M, Chung, Yin Kwan, Dates, Andrew N., de Araujo Farias, Virginea, Del Toro, Daniel, Duman,, Joseph G., Engel, Felix B, Favara, David M., Fu, Chaoyu, De Las Bayonas, Alain Garcia, Georgiadi, Anastasia, Gloriam, David E., Hall, Randy A., Hamann, Jörg, Hildebrand, Peter W., Hsiao, Cheng-Chih, Huang, Bill X., Javitch, Jonathan A., Kim, Hee-Yong, Kittel, Robert J., Kleinau, Gunnar, Leduc, Richard, Liebscher, Ines, Lin, Hsi-Hsien, Linnert, Joshua, Ludwig, Marie-Gabrielle, Martinelli, David C., Mathiasen, Signe, Matúš, Daniel, Melkumyan, Mariam, Moreno-Salinas, Ana L., Mulder, Jan, Nash, Michael A., Pal, Kasturi, Pederick, Daniel T., Perry-Hauser, Nicole A., Piao, Xianhua, Ping, Yu-Qi, Placantonakis, Dimitris G., Pohl, Fabian, Prömel, Simone, Rosenkilde, Mette M, Sabbagh, Laurent, Sando, Richard C., Scheerer, Patrick, Schöneberg, Torsten, Seiradake,, Elena, Selcho, Mareike, Seufert, Florian, Singh, Abhishek K., Skiniotis, Georgios, Spiess, Katja, Sträter, Norbert, Strutt, David, Südhof, Thomas C., Sun, Jinpeng, Tall, Gregory G., Thor, Doreen, Tilley, Douglas G., Tolias, Kimberley F., Vallon, Mario, Van Meir, Erwin G., Vanhollebeke, Benoit, Wiggin, Giselle R., Wolfrum, Uwe, Yan, Jie, Zaidman, Nathan A., Zou, Yimin and Scholz, Nicole (2026) Adhesion G protein-coupled receptors. Pharmacological reviews, 78 (3). ISSN 0031-6997
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Adhesion G protein-coupled receptors (aGPCRs) constitute a structurally and functionally distinct group within the superfamily of GPCRs. In 2015, the International Union of Pharmacology invited the Adhesion GPCR Consortium to publish a comprehensive review about aGPCRs and to establish a unified nomenclature. Since then, substantial progress has been made in delineating the biological roles, molecular architecture, biochemical properties, expression profiles, ligand repertoire, and activation and signaling strategies of aGPCRs. Commensurate with these advances, their relevance to human pathophysiology has become increasingly evident. In a coordinated effort, the Adhesion GPCR Consortium has reviewed recent progress in the field and provides a comprehensive assessment of the current understanding of aGPCR biology here. This includes a focus on human and mammalian aGPCRs, their evolutionary origins, methodological approaches and model systems for their investigation, as well as emerging approaches for their therapeutic targeting.
Item Type Article
Identification Number 10.1016/j.pharmr.2026.100116
Additional information © 2026 The Author(s). Published by Elsevier Inc. on behalf of American Society for Pharmacology and Experimental Therapeutics. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Date Deposited 17 Sep 2026 14:35
Last Modified 17 Sep 2026 14:35

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